Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise

G. L. Pierce, S. A. Harris, D. R. Seals, D. P. Casey, P. B. Barlow, H. M. Stauss

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Abstract

We hypothesised that differences in cardiac baroreflex sensitivity (BRS) would be independently associated with aortic stiffness and augmentation index (AI), clinical biomarkers of cardiovascular disease risk, among young sedentary and middle-aged/older sedentary and endurance-trained adults. A total of 36 healthy middle-aged/older (age 55–76 years, n=22 sedentary and n=14 endurance-trained) and 5 young sedentary (age 18–31 years) adults were included in a cross-sectional study. A subset of the middle-aged/older sedentary adults (n=12) completed an 8-week-aerobic exercise intervention. Invasive brachial artery blood pressure waveforms were used to compute spontaneous cardiac BRS (via sequence technique), estimated aortic pulse wave velocity (PWV) and AI (AI, via brachial–aortic transfer function and wave separation analysis). In the cross-sectional study, cardiac BRS was 71% lower in older compared with young sedentary adults (P2=0.59, P

Original languageEnglish (US)
JournalJournal of Human Hypertension
DOIs
StateAccepted/In press - Feb 25 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Internal Medicine

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