ERCP in the management of early versus late biliary leaks after liver transplantation

Thomas D. Johnston, Kunam Sudhakar Reddy, Taqi T. Khan, Dinesh Ranjan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The role of endoscopy in the management of bile leaks following liver transplantation has been controversial. Bile leak after liver transplantation has an incidence of ∼10% to 15%, and the choice of observation, laparotomy, or endoscopic retrograde pancreatography (ERCP), usually with sphincterotomy and/or placement of a bile duct stent, has depended on the transplant groups' experience and the availability of skilled endoscopists. We report our experience in the management of bile leaks following orthotopic liver transplantation. Between July 11, 1995, and January 22, 2003, there were 174 whole-liver-graft orthotopic liver transplant procedures performed at the University of Kentucky. In 158 of these, the initial bile duct management was by choledochocholedochostomy (duct-to-duct anastomosis) over a small-caliber T-tube. Bile leaks were diagnosed in 21 of 158 patients, with an incidence of 13.3%. Of the early leaks (<30 days post-transplantation), 2 were managed with observation alone, and 12 underwent ERCP. This revealed five anastomotic leaks requiring laparotomy. Of the seven leaks occurring later, six were managed by ERCP and one required laparotomy. With a median follow-up period of 18 months, 18 patients (85.7%) are alive with no further biliary tract problems. ERCP remains a useful adjunct in the management of post-liver transplant bile leaks. It is, however, less likely to be successful in the definitive management of early leaks.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalInternational Surgery
Volume91
Issue number5
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Bile
Liver Transplantation
Laparotomy
Transplants
Bile Ducts
Liver
Observation
Anastomotic Leak
Incidence
Biliary Tract
Endoscopy
Stents
Transplantation

Keywords

  • Bile leak
  • Biliary complication
  • Liver transplantation
  • T-tube

ASJC Scopus subject areas

  • Surgery

Cite this

ERCP in the management of early versus late biliary leaks after liver transplantation. / Johnston, Thomas D.; Reddy, Kunam Sudhakar; Khan, Taqi T.; Ranjan, Dinesh.

In: International Surgery, Vol. 91, No. 5, 09.2006, p. 301-305.

Research output: Contribution to journalArticle

Johnston, Thomas D. ; Reddy, Kunam Sudhakar ; Khan, Taqi T. ; Ranjan, Dinesh. / ERCP in the management of early versus late biliary leaks after liver transplantation. In: International Surgery. 2006 ; Vol. 91, No. 5. pp. 301-305.
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