Abstract
Epigenetics is the study of changes in phenotype or gene expression that take place outside of the DNA sequence. Examples of epigenetic phenomena include the methylation of DNA, acetylation of histones involved in DNA packaging, and the production of microRNAs. Collectively, these processes can alter gene transcription and translation, post-translational modifications, and insertional mutagenesis in order to modify health and disease. In recent years, tremendous in vivo and in vitro evidence has accumulated that replication of hepatitis B virus (HBV), the production of RNA intermediates, as well as antigen expression can be regulated by epigenetic mechanisms. Furthermore, an understanding of the epigenetic regulation of HBV has already been applied toward new approaches in vivo and in small animal models for the treatment of chronic hepatitis B (CHB). These approaches are important steps toward translating this knowledge into improved therapies for humans suffering from this infection, which is a leading cause of liver-related morbidity and mortality globally.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-284 |
| Number of pages | 8 |
| Journal | Current Hepatitis Reports |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2011 |
| Externally published | Yes |
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Keywords
- CpG islands
- Epigenetic
- Hepatitis B virus
- Histone acetylation
- Methylation
- MicroRNA (miRNA)
- Small hairpin RNA (shRNA)
- Small interfering RNA (siRNA)
ASJC Scopus subject areas
- Hepatology
- Virology
Cite this
Epigenetic regulation of hepatitis B virus infection. / Mogul, Douglas; Torbenson, Michael; Schwarz, Kathleen B.
In: Current Hepatitis Reports, Vol. 10, No. 4, 01.12.2011, p. 277-284.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epigenetic regulation of hepatitis B virus infection
AU - Mogul, Douglas
AU - Torbenson, Michael
AU - Schwarz, Kathleen B.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Epigenetics is the study of changes in phenotype or gene expression that take place outside of the DNA sequence. Examples of epigenetic phenomena include the methylation of DNA, acetylation of histones involved in DNA packaging, and the production of microRNAs. Collectively, these processes can alter gene transcription and translation, post-translational modifications, and insertional mutagenesis in order to modify health and disease. In recent years, tremendous in vivo and in vitro evidence has accumulated that replication of hepatitis B virus (HBV), the production of RNA intermediates, as well as antigen expression can be regulated by epigenetic mechanisms. Furthermore, an understanding of the epigenetic regulation of HBV has already been applied toward new approaches in vivo and in small animal models for the treatment of chronic hepatitis B (CHB). These approaches are important steps toward translating this knowledge into improved therapies for humans suffering from this infection, which is a leading cause of liver-related morbidity and mortality globally.
AB - Epigenetics is the study of changes in phenotype or gene expression that take place outside of the DNA sequence. Examples of epigenetic phenomena include the methylation of DNA, acetylation of histones involved in DNA packaging, and the production of microRNAs. Collectively, these processes can alter gene transcription and translation, post-translational modifications, and insertional mutagenesis in order to modify health and disease. In recent years, tremendous in vivo and in vitro evidence has accumulated that replication of hepatitis B virus (HBV), the production of RNA intermediates, as well as antigen expression can be regulated by epigenetic mechanisms. Furthermore, an understanding of the epigenetic regulation of HBV has already been applied toward new approaches in vivo and in small animal models for the treatment of chronic hepatitis B (CHB). These approaches are important steps toward translating this knowledge into improved therapies for humans suffering from this infection, which is a leading cause of liver-related morbidity and mortality globally.
KW - CpG islands
KW - Epigenetic
KW - Hepatitis B virus
KW - Histone acetylation
KW - Methylation
KW - MicroRNA (miRNA)
KW - Small hairpin RNA (shRNA)
KW - Small interfering RNA (siRNA)
UR - http://www.scopus.com/inward/record.url?scp=81355148898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81355148898&partnerID=8YFLogxK
U2 - 10.1007/s11901-011-0113-3
DO - 10.1007/s11901-011-0113-3
M3 - Article
AN - SCOPUS:81355148898
VL - 10
SP - 277
EP - 284
JO - Current Hepatitis Reports
JF - Current Hepatitis Reports
SN - 1540-3416
IS - 4
ER -