TY - JOUR
T1 - Epidemiology of Cutaneous Lupus Erythematosus Among Adults Over Four Decades (1976-2018)
T2 - A Lupus Midwest Network (LUMEN) Study
AU - Hocaoğlu, Mehmet
AU - Davis, Mark Denis P.
AU - Osei-Onomah, Shirley Ann
AU - Valenzuela-Almada, Maria O.
AU - Dabit, Jesse Y.
AU - Duong, Stephanie Q.
AU - Yang, Jeffrey X.
AU - Helmick, Charles G.
AU - Crowson, Cynthia
AU - Duarte-García, Alí
N1 - Funding Information:
Grant Support: The Lupus Midwest Network (LUMEN) project is supported by the Centers for Disease Control and Prevention of the US Department of Health and Human Services under grant number U01 DP006491 as part of a financial assistance award totaling $1,750,000 with 100% funded by the Centers for Disease Control and Prevention/Department of Health and Human Services. The Rochester Epidemiology Project was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG034676 and grant number UL1 TR002377 from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health. This project was funded in part by the career enhancement award in women's health research, Mayo Clinic Center for Women's Health, and the Mayo Clinic Women's Health Research Center.Grant Support: The Lupus Midwest Network (LUMEN) project is supported by the Centers for Disease Control and Prevention of the US Department of Health and Human Services under grant number U01 DP006491 as part of a financial assistance award totaling, 750,000 with 100% funded by the Centers for Disease Control and Prevention/Department of Health and Human Services. The Rochester Epidemiology Project was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG034676 and grant number UL1 TR002377 from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health. This project was funded in part by the career enhancement award in women's health research, Mayo Clinic Center for Women's Health, and the Mayo Clinic Women's Health Research Center.
Funding Information:
Grant Support: The Lupus Midwest Network (LUMEN) project is supported by the Centers for Disease Control and Prevention of the US Department of Health and Human Services under grant number U01 DP006491 as part of a financial assistance award totaling $1,750,000 with 100% funded by the Centers for Disease Control and Prevention / Department of Health and Human Services . The Rochester Epidemiology Project was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG034676 and grant number UL1 TR002377 from the National Center for Advancing Translational Sciences , a component of the National Institutes of Health. This project was funded in part by the career enhancement award in women’s health research, Mayo Clinic Center for Women’s Health, and the Mayo Clinic Women’s Health Research Center.
Publisher Copyright:
© 2022 Mayo Foundation for Medical Education and Research
PY - 2022/12
Y1 - 2022/12
N2 - Objective: To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota. Patients and Methods: In this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project. Results: The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time. Conclusion: In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.
AB - Objective: To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota. Patients and Methods: In this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project. Results: The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time. Conclusion: In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.
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U2 - 10.1016/j.mayocp.2022.06.022
DO - 10.1016/j.mayocp.2022.06.022
M3 - Article
C2 - 36347648
AN - SCOPUS:85142530368
VL - 97
SP - 2282
EP - 2290
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 12
ER -