Eosinophilic-lymphocytic myocarditis after smallpox vaccination

Joseph G. Murphy; R. Scott Wright; G. Keith Bruce; Larry M. Baddour; Michael A. Farrell; William D. Edwards; Hirohito Kita; Leslie T. Cooper

doi:10.1016/S0140-6736(03)14635-1

Eosinophilic-lymphocytic myocarditis after smallpox vaccination

Joseph G. Murphy, R. Scott Wright, G. Keith Bruce, Larry M. Baddour, Michael A. Farrell, William D. Edwards, Hirohito Kita, Leslie T. Cooper

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Smallpox is an eradicated viral disease that has re-emerged as a potential bioterrorism threat. Smallpox vaccination was historically the most effective defence measure against wild smallpox virus. The risk of myopericarditis after vaccination might limit this option. We report a case of biopsy-proven eosinophilic-lymphocytic myocarditis diagnosed in vivo with histological evidence for eosinophil-mediated cardiac myocyte necrosis shortly after smallpox vaccination. Furthermore, we report a beneficial haemodynamic response to high-dose corticosteroids. A better understanding of the aberrant immune mechanism of myocyte injury after smallpox vaccination might improve the risk/benefit assessment for people considering smallpox vaccination and better smallpox vaccines in the future.

Original language	English (US)
Pages (from-to)	1378-1380
Number of pages	3
Journal	Lancet
Volume	362
Issue number	9393
DOIs	https://doi.org/10.1016/S0140-6736(03)14635-1
State	Published - Oct 25 2003

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(03)14635-1

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title = "Eosinophilic-lymphocytic myocarditis after smallpox vaccination",

abstract = "Smallpox is an eradicated viral disease that has re-emerged as a potential bioterrorism threat. Smallpox vaccination was historically the most effective defence measure against wild smallpox virus. The risk of myopericarditis after vaccination might limit this option. We report a case of biopsy-proven eosinophilic-lymphocytic myocarditis diagnosed in vivo with histological evidence for eosinophil-mediated cardiac myocyte necrosis shortly after smallpox vaccination. Furthermore, we report a beneficial haemodynamic response to high-dose corticosteroids. A better understanding of the aberrant immune mechanism of myocyte injury after smallpox vaccination might improve the risk/benefit assessment for people considering smallpox vaccination and better smallpox vaccines in the future.",

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T1 - Eosinophilic-lymphocytic myocarditis after smallpox vaccination

AU - Murphy, Joseph G.

AU - Wright, R. Scott

AU - Bruce, G. Keith

AU - Baddour, Larry M.

AU - Farrell, Michael A.

AU - Edwards, William D.

AU - Kita, Hirohito

AU - Cooper, Leslie T.

PY - 2003/10/25

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AB - Smallpox is an eradicated viral disease that has re-emerged as a potential bioterrorism threat. Smallpox vaccination was historically the most effective defence measure against wild smallpox virus. The risk of myopericarditis after vaccination might limit this option. We report a case of biopsy-proven eosinophilic-lymphocytic myocarditis diagnosed in vivo with histological evidence for eosinophil-mediated cardiac myocyte necrosis shortly after smallpox vaccination. Furthermore, we report a beneficial haemodynamic response to high-dose corticosteroids. A better understanding of the aberrant immune mechanism of myocyte injury after smallpox vaccination might improve the risk/benefit assessment for people considering smallpox vaccination and better smallpox vaccines in the future.

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Eosinophilic-lymphocytic myocarditis after smallpox vaccination

Abstract

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