Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Matthieu Groh, Christian Pagnoux, Chiara Baldini, Elisabeth Bel, Paolo Bottero, Vincent Cottin, Klaus Dalhoff, Bertrand Dunogué, Wolfgang Gross, Julia Holle, Marc Humbert, David Jayne, J. Charles Jennette, Romain Lazor, Alfred Mahr, Peter A. Merkel, Luc Mouthon, Renato Alberto Sinico, Ulrich Specks, Augusto VaglioMichael E. Wechsler, Jean François Cordier, Loïc Guillevin

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalEuropean Journal of Internal Medicine
Volume26
Issue number7
DOIs
StatePublished - Sep 1 2015

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Granulomatosis with Polyangiitis
Advisory Committees
Hypereosinophilic Syndrome
Churg-Strauss Syndrome
Physiologic Monitoring
Vasculitis
Publications
Cytoplasm
Asthma
Physicians
Antibodies
Research
Therapeutics
Rheumatologists
Pulmonologists
Allergists
Pathologists
Nephrologists

Keywords

  • Anti-neutrophil cytoplasm antibody-associated vasculitis
  • Asthma
  • Churg-Strauss syndrome
  • Eosinophilia
  • Eosinophilic granulomatosis with polyangiitis
  • Recommendations

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. / Groh, Matthieu; Pagnoux, Christian; Baldini, Chiara; Bel, Elisabeth; Bottero, Paolo; Cottin, Vincent; Dalhoff, Klaus; Dunogué, Bertrand; Gross, Wolfgang; Holle, Julia; Humbert, Marc; Jayne, David; Jennette, J. Charles; Lazor, Romain; Mahr, Alfred; Merkel, Peter A.; Mouthon, Luc; Sinico, Renato Alberto; Specks, Ulrich; Vaglio, Augusto; Wechsler, Michael E.; Cordier, Jean François; Guillevin, Loïc.

In: European Journal of Internal Medicine, Vol. 26, No. 7, 01.09.2015, p. 545-553.

Research output: Contribution to journalArticle

Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, JC, Lazor, R, Mahr, A, Merkel, PA, Mouthon, L, Sinico, RA, Specks, U, Vaglio, A, Wechsler, ME, Cordier, JF & Guillevin, L 2015, 'Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management', European Journal of Internal Medicine, vol. 26, no. 7, pp. 545-553. https://doi.org/10.1016/j.ejim.2015.04.022
Groh, Matthieu ; Pagnoux, Christian ; Baldini, Chiara ; Bel, Elisabeth ; Bottero, Paolo ; Cottin, Vincent ; Dalhoff, Klaus ; Dunogué, Bertrand ; Gross, Wolfgang ; Holle, Julia ; Humbert, Marc ; Jayne, David ; Jennette, J. Charles ; Lazor, Romain ; Mahr, Alfred ; Merkel, Peter A. ; Mouthon, Luc ; Sinico, Renato Alberto ; Specks, Ulrich ; Vaglio, Augusto ; Wechsler, Michael E. ; Cordier, Jean François ; Guillevin, Loïc. / Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. In: European Journal of Internal Medicine. 2015 ; Vol. 26, No. 7. pp. 545-553.
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abstract = "Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.",
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AU - Pagnoux, Christian

AU - Baldini, Chiara

AU - Bel, Elisabeth

AU - Bottero, Paolo

AU - Cottin, Vincent

AU - Dalhoff, Klaus

AU - Dunogué, Bertrand

AU - Gross, Wolfgang

AU - Holle, Julia

AU - Humbert, Marc

AU - Jayne, David

AU - Jennette, J. Charles

AU - Lazor, Romain

AU - Mahr, Alfred

AU - Merkel, Peter A.

AU - Mouthon, Luc

AU - Sinico, Renato Alberto

AU - Specks, Ulrich

AU - Vaglio, Augusto

AU - Wechsler, Michael E.

AU - Cordier, Jean François

AU - Guillevin, Loïc

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N2 - Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

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