ENvironmental dynamics underlying responsive extreme survivors (ENDURES) of glioblastoma: A multidisciplinary team-based, multifactorial analytical approach

Sandra K. Johnston, Paula Whitmire, Susan C. Massey, Priya Kumthekar, Alyx B. Porter, Natarajan Raghunand, Luis F. Gonzalez-Cuyar, Maciej M. Mrugala, Andrea Hawkins-Daarud, Pamela R. Jackson, Leland S. Hu, Jann N. Sarkaria, Lei Wang, Robert A. Gatenby, Kathleen M. Egan, Peter Canoll, Kristin R. Swanson

Research output: Contribution to journalArticlepeer-review

Abstract

Although glioblastoma (GBM) is a fatal primary brain cancer with short median survival of 15 months, a small number of patients survive >5 years after diagnosis; they are known as extreme survivors (ES). Because of their rarity, very little is known about what differentiates these outliers from other patients with GBM. For the purpose of identifying unknown drivers of extreme survivorship in GBM, the ENDURES consortium (ENvironmental Dynamics Underlying Responsive Extreme Survivors of GBM) was developed. This consortium is a multicenter collaborative network of investigators focused on the integration of multiple types of clinical data and the creation of patient-specific models of tumor growth informed by radiographic and histologic parameters. Leveraging our combined resources, the goals of the ENDURES consortium are 2-fold: (1) to build a curated, searchable, multilayered repository housing clinical and outcome data on a large cohort of ES patients with GBM; and (2) to leverage the ENDURES repository for new insights into tumor behavior and novel targets for prolonging survival for all patients with GBM. In this article, the authors review the available literature and discuss what is already known about ES. The authors then describe the creation of their consortium and some preliminary results.

Original languageEnglish (US)
Pages (from-to)655-661
Number of pages7
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume42
Issue number8
DOIs
StatePublished - Aug 1 2019

Keywords

  • ENDURES consortium
  • brain tumor repository
  • extreme survival
  • glioblastoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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