Enhancing the therapeutic index of radiation in multiple myeloma

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3 Scopus citations


Multiple myeloma is a systemic malignancy that remains incurable with current therapy. Myeloma is highly radiosensitive, and radiation-based therapies have the potential to provide significant clinical benefit. Effective deployment of radiotherapy as a systemic modality in myeloma depends on maximizing its therapeutic index by efficiently and accurately delivering the radiation to sites of myeloma cell growth and increasing the radiosensitivity of myeloma cells relative to normal tissues. In this review, we discuss various strategies that are currently under investigation to enhance clinical benefit of radiotherapy in multiple myeloma.

Original languageEnglish (US)
Pages (from-to)515-522
Number of pages8
JournalDrug Discovery Today: Disease Mechanisms
Issue number4
StatePublished - 2006


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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