Endoluminal gastroplication for the treatment of gastroesophageal reflux disease: A 2-year prospective pilot study from Taiwan

Chien Chung Liao, Chia Long Lee, Bor Ru Lin, Chyi Huey Bai, Yu Hsia Hsieh, Chi Hwa Wu, Christopher J. Gostout

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background and Aim: Endoluminal gastroplication (ELGP) offers a minimally invasive option for the treatment of gastroesophageal reflux disease (GERD) in Western countries. However, long-term outcomes of ELGP in Asian populations have not been investigated. The aim of this prospective study was to evaluate the long-term benefits of ELGP in Asian patients with GERD. Methods: Taiwanese patients diagnosed with GERD were enrolled and had the procedure performed with EndoCinch. The assessment included symptom scoring, validated GERD questionnaires, esophagogastroduodenoscopy, esophageal manometry and 24-h pH monitoring before and after the procedure over a 2-year period. Results: Twenty-one consecutive patients were recruited and underwent ELGP. Patients reported improved heartburn symptom score (mean 64.0 vs 21.1, P < 0.001), regurgitation frequency score (mean 2.4 vs 1.3, P < 0.001), and GERD health-related quality of life (mean 23.1 vs 10.1, P < 0.001) at 24 months. The mean total time of pH < 4 reduced from 121.7 min to 67.1 min (P = 0.008) and mean DeMeester score reduced from 32.9 to 17.6 (P = 0.011) at 3 months. Antisecretory drug discontinuation rate was 81%, 57%, 52% and 48% at 1, 6, 12 and 24 months, respectively. Of the patients who had a favorable initial response to ELGP at 1 month, 41% resumed antisecretory medications at 24 months follow-up. All adverse events were mild and transient. Conclusions: Endoluminal gastroplication is a safe and modestly effective endotherapy for patients with GERD. It significantly improved symptoms in an Asian population. Approximately one in two patients continues to be off medication at 24 months follow-up. However, the long-term efficacy and durability are still to be determined.

Original languageEnglish (US)
Pages (from-to)398-405
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume23
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • EndoCinch
  • Endoluminal gastroplication
  • Gastroesophageal reflux disease

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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