Endocrine impact of pure estradiol replacement in postmenopausal women: Alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations

Johannes D Veldhuis, Eugene Samojlik, William S. Evans, Alan D. Rogol, Chester E. Ridgeway, William F. Crowley, Lisa Kolp, Eva Checinska, Marvin A. Kirschner, Michael O. Thorner, Paul Stumpf

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Thirteen healthy postmenopausal volunteers were studied under basal conditions and at intervals (days 1, 5, 10, and 30) after intravaginal placement of a polysiloxane ring impregnated with 400 mg of estradiol. Mean serum estradiol concentrations rose 26-fold with a twofold increase in serum estrone concentrations. Serum Δ4-androstenedione, dehydroepiandrosterone sulfate, and total testosterone did not change, but absolute and percent free testosterone concentrations declined significantly by day 5. Concurrently, serum concentrations of immunoactive follicle-stimulating hormone declined progressively, while serum luteinizing hormone and free α-subunit concentrations exhibited a biphasic pattern of suppression. Serum levels of prolactin increased monophasically and those of growth hormone, somatomedin C, and thyroid-stimulating hormone did not change.

Original languageEnglish (US)
Pages (from-to)334-339
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume155
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Estradiol
  • gonadotropins
  • menopause
  • pituitary
  • sex steroids

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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    Veldhuis, J. D., Samojlik, E., Evans, W. S., Rogol, A. D., Ridgeway, C. E., Crowley, W. F., Kolp, L., Checinska, E., Kirschner, M. A., Thorner, M. O., & Stumpf, P. (1986). Endocrine impact of pure estradiol replacement in postmenopausal women: Alterations in anterior pituitary hormone release and circulating sex steroid hormone concentrations. American Journal of Obstetrics and Gynecology, 155(2), 334-339. https://doi.org/10.1016/0002-9378(86)90821-5