End of life, withdrawal, and palliative care utilization among patients receiving maintenance hemodialysis therapy

Joy Chieh Yu Chen, Bjorg Thorsteinsdottir, Lisa E. Vaughan, Molly A. Feely, Robert C. Albright, Macaulay Onuigbo, Suzanne M. Norby, Christy L. Gossett, Margaret M. D’Uscio, Amy W. Williams, John J Dillon, La Tonya J. Hickson

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background and objectives Withdrawal from maintenance hemodialysis before death has become more common because of high disease and treatment burden. The study objective was to identify patient factors and examine the terminal course associated with hemodialysis withdrawal, and assess patterns of palliative care involvement before death among patients on maintenance hemodialysis. Design, setting, participants, & measurements We designed an observational cohort study of adult patients on incident hemodialysis in a midwestern United States tertiary center, from January 2001 to November 2013, with death events through to November 2015. Logistic regression models evaluated associations between patient characteristics and withdrawal status and palliative care service utilization. Results Among 1226 patients, 536 died and 262 (49% of 536) withdrew. A random sample (10%; 52 out of 536) review of Death Notification Forms revealed 73% sensitivity for withdrawal. Risk factors for withdrawal before death included older age, white race, palliative care consultation within 6 months, hospitalization within 30 days, cerebrovascular disease, and no coronary artery disease. Most withdrawal decisions were made by patients (60%) or a family member (33%; surrogates). The majority withdrew either because of acute medical complications (51%) or failure to thrive/ frailty (22%). After withdrawal, median time to death was 7 days (interquartile range, 4-11). In hospital deaths were less common in the withdrawal group (34% versus 46% non withdrawal, P=0.003). A third (34%; 90 out of 262) of those that withdrew received palliative care services. Palliative care consultation in the withdrawal group was associated with longer hemodialysis duration (odds ratio, 1.19 per year; 95% confidence interval, 1.10 to 1.3; P<0.001), hospitalization within 30 days of death (odds ratio, 5.78; 95% confidence interval, 2.62 to 12.73; P<0.001), and death in hospital (odds ratio, 1.92; 95% confidence interval, 1.13 to 3.27; P=0.02). Conclusions In this single-center study, the rate of hemodialysis withdrawals were twice the frequency previously described. Acute medical complications and frailty appeared to be driving factors. However, palliative care services were used in only a minority of patients.

Original languageEnglish (US)
Pages (from-to)1172-1179
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume13
Issue number8
DOIs
StatePublished - Aug 7 2018

Keywords

  • Chronic hemodialysis
  • Cohort Studies
  • Death notification form
  • Diabetes
  • End stage kidney disease
  • Frailty
  • Geriatric medicine
  • Geriatric nephrology
  • Goals of care
  • Healthcare power of attorney
  • Hemodialysis withdrawal
  • Hospice
  • Hospital Mortality
  • Hospitalization
  • Intensive care unit
  • Logistic Models
  • Mortality
  • Palliative care
  • Palliative nephrology
  • Referral and Consultation
  • Risk factors
  • Terminal Care

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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    Chen, J. C. Y., Thorsteinsdottir, B., Vaughan, L. E., Feely, M. A., Albright, R. C., Onuigbo, M., Norby, S. M., Gossett, C. L., D’Uscio, M. M., Williams, A. W., Dillon, J. J., & Hickson, L. T. J. (2018). End of life, withdrawal, and palliative care utilization among patients receiving maintenance hemodialysis therapy. Clinical Journal of the American Society of Nephrology, 13(8), 1172-1179. https://doi.org/10.2215/CJN.00590118