Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease

Koa Hosoki; Masahiro Hirayama; Gail M. Kephart; Hirohito Kita; Mizuho Nagao; Hiromasa Uchizono; Hidemi Toyoda; Yuko Senba; Yu Imai; Yoshihiro Komada; Toshiaki Ihara; Takao Fujisawa

doi:10.1159/000337777

Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease

Koa Hosoki, Masahiro Hirayama, Gail M. Kephart, Hirohito Kita, Mizuho Nagao, Hiromasa Uchizono, Hidemi Toyoda, Yuko Senba, Yu Imai, Yoshihiro Komada, Toshiaki Ihara, Takao Fujisawa

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5-and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	International archives of allergy and immunology
Volume	158
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000337777
State	Published - May 2012

Keywords

Eosinophilia
Interleukin-10
Interleukin-5
Kimura disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000337777

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title = "Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease",

abstract = "Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5-and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.",

keywords = "Eosinophilia, Interleukin-10, Interleukin-5, Kimura disease",

author = "Koa Hosoki and Masahiro Hirayama and Kephart, {Gail M.} and Hirohito Kita and Mizuho Nagao and Hiromasa Uchizono and Hidemi Toyoda and Yuko Senba and Yu Imai and Yoshihiro Komada and Toshiaki Ihara and Takao Fujisawa",

year = "2012",

month = may,

doi = "10.1159/000337777",

language = "English (US)",

volume = "158",

pages = "70--74",

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AU - Hosoki, Koa

AU - Hirayama, Masahiro

AU - Kephart, Gail M.

AU - Kita, Hirohito

AU - Nagao, Mizuho

AU - Uchizono, Hiromasa

AU - Toyoda, Hidemi

AU - Senba, Yuko

AU - Imai, Yu

AU - Komada, Yoshihiro

AU - Ihara, Toshiaki

AU - Fujisawa, Takao

PY - 2012/5

Y1 - 2012/5

N2 - Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5-and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

AB - Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5-and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

KW - Eosinophilia

KW - Interleukin-10

KW - Interleukin-5

KW - Kimura disease

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ER -

Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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