Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease

Koa Hosoki, Masahiro Hirayama, Gail M. Kephart, Hirohito Kita, Mizuho Nagao, Hiromasa Uchizono, Hidemi Toyoda, Yuko Senba, Yu Imai, Yoshihiro Komada, Toshiaki Ihara, Takao Fujisawa

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5-and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalInternational archives of allergy and immunology
Volume158
Issue numberSUPPL. 1
DOIs
StatePublished - May 2012

Keywords

  • Eosinophilia
  • Interleukin-10
  • Interleukin-5
  • Kimura disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hosoki, K., Hirayama, M., Kephart, G. M., Kita, H., Nagao, M., Uchizono, H., Toyoda, H., Senba, Y., Imai, Y., Komada, Y., Ihara, T., & Fujisawa, T. (2012). Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease. International archives of allergy and immunology, 158(SUPPL. 1), 70-74. https://doi.org/10.1159/000337777