Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis

J. R. Lopez, N. Linares, G. Cordovez, Andre Terzic

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Exertional rhabdomyolysis is a myopathy of unknown pathophysiology. We measured intracellular resting calcium concentration ([Ca2+](i))by means of Ca2+-selective microelectrodes in intercostal muscle fibers from horses suffering from rhabdomyolysis, and from horses with no evidence of neuromuscular disorder. [Ca2+](i) was several fold higher in muscle fibers from horses suffering from rhabdomyolysis when compared to controls. Treatment of rhabdomyolytic horses with dantrolene, an agent that prevents Ca2+ release from the sarcoplasmic reticulum, reduced [Ca2+](i) toward control values, and accelerated the recovery from this myopathy. These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+](i) in skeletal muscles, and that dantrolene might be of benefit in treating this disease.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume430
Issue number2
DOIs
StatePublished - 1995

Fingerprint

Rhabdomyolysis
Horses
Dantrolene
Muscle
Calcium
Muscular Diseases
Fibers
Microelectrodes
Intercostal Muscles
Sarcoplasmic Reticulum
Recovery
Skeletal Muscle
Muscles

Keywords

  • calcium
  • dantrolene
  • rhabdomyolysis
  • skeletal muscle

ASJC Scopus subject areas

  • Physiology

Cite this

Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis. / Lopez, J. R.; Linares, N.; Cordovez, G.; Terzic, Andre.

In: Pflugers Archiv European Journal of Physiology, Vol. 430, No. 2, 1995, p. 293-295.

Research output: Contribution to journalArticle

Lopez, J. R. ; Linares, N. ; Cordovez, G. ; Terzic, Andre. / Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis. In: Pflugers Archiv European Journal of Physiology. 1995 ; Vol. 430, No. 2. pp. 293-295.
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