Elevated myoplasmic calcium in exercise-induced equine rhabdomyolysis

J. R. López, N. Linares, G. Cordovez, A. Terzic

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Exertional rhabdomyolysis is a myopathy of unknown pathophysiology. We measured intracellular resting calcium concentration ([Ca2+]i) by means of Ca2+-selective microelectrodes in intercostal muscle fibers from horses suffering from rhabdomyolysis, and from horses with no evidence of neuromuscular disorder. [Ca2+]i was several-fold higher in muscle fibers from horses suffering from rhabdomyolysis when compared to controls. Treatment of rhabdomyolytic horses with dantrolene, an agent that prevents Ca2+ release from the sarcoplasmic reticulum, reduced [Ca2+]i toward control values, and accelerated the recovery from this myopathy. These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+]i in skeletal muscles, and that dantrolene might be of benefit in treating this disease.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume430
Issue number2
DOIs
StatePublished - Jun 1 1995

Keywords

  • Calcium
  • Dantrolene
  • Rhabdomyolysis
  • Skeletal Muscle

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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