Electron-beam CT

Use of a calibration phantom to reduce variability in calcium quantitation

Cynthia H McCollough, R. B. Kaufmann, B. M. Cameron, D. J. Katz, P. F. Sheedy, P. A. Peyser

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

PURPOSE: To measure scanner and patient variation in computed tomographic (CT) numbers for electron-beam CT and to determine the ability of calibration phantoms to reduce variability in calcium quantitation. MATERIALS AND METHODS: Two calibration phantoms were imaged to ensure longitudinal homogeneity and to determine the short-term intrascanner variation in CT numbers. Each phantom set was imaged twice a day for 14 weeks to determine intra- and interscanner variation. Data from examinations of 167 patients that included the phantom were analyzed to determine the intra- and interpatient variation in CT numbers of objects with known calcium concentrations. RESULTS: The calibration reduced scanner variations by approximately 25%. The calcium concentration associated with a CT number of 130 HU varied from 77.1 to 136.4 mg/cm3 and was dependent on patient girth, sex, smoking history, and image level. CONCLUSION: Scanner and patient variations in CT numbers in electron-beam CT can be reduced with a calibration phantom. In vitro and in vivo estimates of calcium concentration had a precision of 2% and 7%, respectively.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalRadiology
Volume196
Issue number1
StatePublished - 1995

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Calibration
Electrons
Calcium
Aptitude
Smoking
History

Keywords

  • Computed tomography (CT), electron beam
  • Computed tomography (CT), physics
  • Coronary vessels, calcification
  • Phantoms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

McCollough, C. H., Kaufmann, R. B., Cameron, B. M., Katz, D. J., Sheedy, P. F., & Peyser, P. A. (1995). Electron-beam CT: Use of a calibration phantom to reduce variability in calcium quantitation. Radiology, 196(1), 159-165.

Electron-beam CT : Use of a calibration phantom to reduce variability in calcium quantitation. / McCollough, Cynthia H; Kaufmann, R. B.; Cameron, B. M.; Katz, D. J.; Sheedy, P. F.; Peyser, P. A.

In: Radiology, Vol. 196, No. 1, 1995, p. 159-165.

Research output: Contribution to journalArticle

McCollough, CH, Kaufmann, RB, Cameron, BM, Katz, DJ, Sheedy, PF & Peyser, PA 1995, 'Electron-beam CT: Use of a calibration phantom to reduce variability in calcium quantitation', Radiology, vol. 196, no. 1, pp. 159-165.
McCollough CH, Kaufmann RB, Cameron BM, Katz DJ, Sheedy PF, Peyser PA. Electron-beam CT: Use of a calibration phantom to reduce variability in calcium quantitation. Radiology. 1995;196(1):159-165.
McCollough, Cynthia H ; Kaufmann, R. B. ; Cameron, B. M. ; Katz, D. J. ; Sheedy, P. F. ; Peyser, P. A. / Electron-beam CT : Use of a calibration phantom to reduce variability in calcium quantitation. In: Radiology. 1995 ; Vol. 196, No. 1. pp. 159-165.
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AU - Sheedy, P. F.

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AB - PURPOSE: To measure scanner and patient variation in computed tomographic (CT) numbers for electron-beam CT and to determine the ability of calibration phantoms to reduce variability in calcium quantitation. MATERIALS AND METHODS: Two calibration phantoms were imaged to ensure longitudinal homogeneity and to determine the short-term intrascanner variation in CT numbers. Each phantom set was imaged twice a day for 14 weeks to determine intra- and interscanner variation. Data from examinations of 167 patients that included the phantom were analyzed to determine the intra- and interpatient variation in CT numbers of objects with known calcium concentrations. RESULTS: The calibration reduced scanner variations by approximately 25%. The calcium concentration associated with a CT number of 130 HU varied from 77.1 to 136.4 mg/cm3 and was dependent on patient girth, sex, smoking history, and image level. CONCLUSION: Scanner and patient variations in CT numbers in electron-beam CT can be reduced with a calibration phantom. In vitro and in vivo estimates of calcium concentration had a precision of 2% and 7%, respectively.

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