TY - JOUR
T1 - Electrocardiographic predictors of coronary microvascular dysfunction in patients with non-obstructive coronary artery disease
T2 - Utility of a novel T wave analysis program
AU - Sara, Jaskanwal D.
AU - Sugrue, Alan
AU - Kremen, Vaclav
AU - Qiang, Bo
AU - Sapir, Yehu
AU - Attia, Zachi I.
AU - Ackerman, Michael J.
AU - Friedman, Paul A.
AU - Lerman, Amir
AU - Noseworthy, Peter A.
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Background Coronary microvascular dysfunction (CMD) is linked to adverse cardiovascular events. Definitive diagnosis of CMD requires invasive provocative testing during angiography. We developed and tested a novel computerized T wave analysis tool to identify electrocardiographic signatures of CMD. Methods 1552 patients underwent an invasive assessment of coronary microvascular function. Patients with interpretable pre-procedural ECGs were divided into 2 age and sex matched groups (n = 261 in each group, 75% female): normal microvascular function, CFR > 2.5 (CFR +), and abnormal microvascular function, CFR ≤ 2.5 (CFR -). ECGs were evaluated using a novel T wave program that quantified subtle changes in T wave morphology. Results T wave repolarization parameters were significantly different between patients with normal and abnormal microvascular function. The top 3 features in males comprised of T wave area in V6 (CFR +: 10091.4 mV2 vs. CFR -: 8152.3 mV2, p < 0.05); T1 Y-center of gravity in lead II (CFR +: 17.8 mV vs. CFR -: 22.4, p < 0.005) and T Peak-T End in lead II (CFR +: 97.6 msec vs. CFR -: 91.1 msec, p < 0.05). These could identify the presence of an abnormal CFR with 74 ± 0.2% accuracy. In females, the top 3 features were T wave right slope lead V6 (CFR +: - 2489.1 mV/msec vs. CFR -: - 2352.3 mV/msec, p < 0.005); Amplitude in V6 (CFR +: 190.4 mV vs. 172.7 mV, p = 0.05) and Y-center of gravity in lead V1 (CFR +: 33.3 vs. CFR -: 40.0, p = 0.001). These features could identify the presence of an abnormal CFR with 67 ± 0.3% accuracy. Conclusion Our data demonstrates that a computer-based repolarization measurement tool may identify electrocardiographic signatures of CMD.
AB - Background Coronary microvascular dysfunction (CMD) is linked to adverse cardiovascular events. Definitive diagnosis of CMD requires invasive provocative testing during angiography. We developed and tested a novel computerized T wave analysis tool to identify electrocardiographic signatures of CMD. Methods 1552 patients underwent an invasive assessment of coronary microvascular function. Patients with interpretable pre-procedural ECGs were divided into 2 age and sex matched groups (n = 261 in each group, 75% female): normal microvascular function, CFR > 2.5 (CFR +), and abnormal microvascular function, CFR ≤ 2.5 (CFR -). ECGs were evaluated using a novel T wave program that quantified subtle changes in T wave morphology. Results T wave repolarization parameters were significantly different between patients with normal and abnormal microvascular function. The top 3 features in males comprised of T wave area in V6 (CFR +: 10091.4 mV2 vs. CFR -: 8152.3 mV2, p < 0.05); T1 Y-center of gravity in lead II (CFR +: 17.8 mV vs. CFR -: 22.4, p < 0.005) and T Peak-T End in lead II (CFR +: 97.6 msec vs. CFR -: 91.1 msec, p < 0.05). These could identify the presence of an abnormal CFR with 74 ± 0.2% accuracy. In females, the top 3 features were T wave right slope lead V6 (CFR +: - 2489.1 mV/msec vs. CFR -: - 2352.3 mV/msec, p < 0.005); Amplitude in V6 (CFR +: 190.4 mV vs. 172.7 mV, p = 0.05) and Y-center of gravity in lead V1 (CFR +: 33.3 vs. CFR -: 40.0, p = 0.001). These features could identify the presence of an abnormal CFR with 67 ± 0.3% accuracy. Conclusion Our data demonstrates that a computer-based repolarization measurement tool may identify electrocardiographic signatures of CMD.
KW - Coronary microvascular dysfunction
KW - Non-obstructive coronary artery disease
KW - QT interval prolongation
KW - T wave morphology
KW - Ventricular arrhythmia
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U2 - 10.1016/j.ijcard.2015.10.228
DO - 10.1016/j.ijcard.2015.10.228
M3 - Article
C2 - 26580336
AN - SCOPUS:84952933496
SN - 0167-5273
VL - 203
SP - 601
EP - 606
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -