TY - JOUR
T1 - Electrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy
AU - Han, Chun Lei
AU - Hu, Wei
AU - Stead, Matt
AU - Zhang, Tan
AU - Zhang, Jian Guo
AU - Worrell, Gregory A.
AU - Meng, Fan Gang
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014
Y1 - 2014
N2 - Temporal lobe epilepsy (TLE) is the most common epilepsy syndrome and is often associated with pharmacoresistance. Patients with pharmacoresistant TLE may be candidates for epilepsy surgery, and anterior temporal lobectomy if indicated is the most effective known treatment and has the best chance of a seizure-free outcome. For many patients with TLE, epilepsy surgery is not an option, for example when the seizure onset zone co-localizes with eloquent brain function and cannot be resected, or the seizure onset zone is not well localized, or when seizures independently originate from both temporal lobes. For many of these patients, electrical stimulation is a viable treatment option, such as electrical stimulation of the hippocampus, or temporal neocortex, or thalamus. Animal and clinical studies in humans have demonstrated electrical stimulation is an effective and safe treatment. Moreover, successful application of responsive neurostimulation system in the treatment of temporal lobe epilepsy has been reported recently. This review is intended to provide a comprehensive review of the modern history of electrical stimulation of the hippocampus for the treatment of refractory medial temporal lobe epilepsy and discuss the anatomical basis, validity, side effects, stimulation paradigm and mechanism of hippocampus stimulation and the responsive electrical stimulation trials.
AB - Temporal lobe epilepsy (TLE) is the most common epilepsy syndrome and is often associated with pharmacoresistance. Patients with pharmacoresistant TLE may be candidates for epilepsy surgery, and anterior temporal lobectomy if indicated is the most effective known treatment and has the best chance of a seizure-free outcome. For many patients with TLE, epilepsy surgery is not an option, for example when the seizure onset zone co-localizes with eloquent brain function and cannot be resected, or the seizure onset zone is not well localized, or when seizures independently originate from both temporal lobes. For many of these patients, electrical stimulation is a viable treatment option, such as electrical stimulation of the hippocampus, or temporal neocortex, or thalamus. Animal and clinical studies in humans have demonstrated electrical stimulation is an effective and safe treatment. Moreover, successful application of responsive neurostimulation system in the treatment of temporal lobe epilepsy has been reported recently. This review is intended to provide a comprehensive review of the modern history of electrical stimulation of the hippocampus for the treatment of refractory medial temporal lobe epilepsy and discuss the anatomical basis, validity, side effects, stimulation paradigm and mechanism of hippocampus stimulation and the responsive electrical stimulation trials.
KW - Deep brain stimulation
KW - Epilepsy
KW - Hippocampus
KW - Responsive neurostimulation system
KW - Temporal lobe
UR - http://www.scopus.com/inward/record.url?scp=84908297692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908297692&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2014.08.007
DO - 10.1016/j.brainresbull.2014.08.007
M3 - Review article
C2 - 25200252
AN - SCOPUS:84908297692
SN - 0361-9230
VL - 109
SP - 13
EP - 21
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -