Electrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy

Chun Lei Han, Wei Hu, Squire Matthew Stead, Tan Zhang, Jian Guo Zhang, Gregory Alan Worrell, Fan Gang Meng

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Temporal lobe epilepsy (TLE) is the most common epilepsy syndrome and is often associated with pharmacoresistance. Patients with pharmacoresistant TLE may be candidates for epilepsy surgery, and anterior temporal lobectomy if indicated is the most effective known treatment and has the best chance of a seizure-free outcome. For many patients with TLE, epilepsy surgery is not an option, for example when the seizure onset zone co-localizes with eloquent brain function and cannot be resected, or the seizure onset zone is not well localized, or when seizures independently originate from both temporal lobes. For many of these patients, electrical stimulation is a viable treatment option, such as electrical stimulation of the hippocampus, or temporal neocortex, or thalamus. Animal and clinical studies in humans have demonstrated electrical stimulation is an effective and safe treatment. Moreover, successful application of responsive neurostimulation system in the treatment of temporal lobe epilepsy has been reported recently. This review is intended to provide a comprehensive review of the modern history of electrical stimulation of the hippocampus for the treatment of refractory medial temporal lobe epilepsy and discuss the anatomical basis, validity, side effects, stimulation paradigm and mechanism of hippocampus stimulation and the responsive electrical stimulation trials.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalBrain Research Bulletin
Volume109
DOIs
StatePublished - 2014

Fingerprint

Temporal Lobe Epilepsy
Electric Stimulation
Hippocampus
Seizures
Epilepsy
Anterior Temporal Lobectomy
Therapeutics
Modern 1601-history
Neocortex
Temporal Lobe
Thalamus
Brain

Keywords

  • Deep brain stimulation
  • Epilepsy
  • Hippocampus
  • Responsive neurostimulation system
  • Temporal lobe

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy. / Han, Chun Lei; Hu, Wei; Stead, Squire Matthew; Zhang, Tan; Zhang, Jian Guo; Worrell, Gregory Alan; Meng, Fan Gang.

In: Brain Research Bulletin, Vol. 109, 2014, p. 13-21.

Research output: Contribution to journalArticle

Han, Chun Lei ; Hu, Wei ; Stead, Squire Matthew ; Zhang, Tan ; Zhang, Jian Guo ; Worrell, Gregory Alan ; Meng, Fan Gang. / Electrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy. In: Brain Research Bulletin. 2014 ; Vol. 109. pp. 13-21.
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