Electrical stimulation facilitates rat facial nerve recovery from a crush injury

Devyani Lal; Laura T. Hetzler; Nijee Sharma; Robert D. Wurster; Sam J. Marzo; Kathryn J. Jones; Eileen M. Foecking

doi:10.1016/j.otohns.2008.04.030

Electrical stimulation facilitates rat facial nerve recovery from a crush injury

Devyani Lal, Laura T. Hetzler, Nijee Sharma, Robert D. Wurster, Sam J. Marzo, Kathryn J. Jones, Eileen M. Foecking

Otolaryngology- Head & Neck Surgery/Audiology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Objective: To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model. Study Design: Experimental. Method: The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement. Results: An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time. Conclusion: Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.

Original language	English (US)
Pages (from-to)	68-73
Number of pages	6
Journal	Otolaryngology - Head and Neck Surgery
Volume	139
Issue number	1
DOIs	https://doi.org/10.1016/j.otohns.2008.04.030
State	Published - Jul 2008

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1016/j.otohns.2008.04.030

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title = "Electrical stimulation facilitates rat facial nerve recovery from a crush injury",

abstract = "Objective: To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model. Study Design: Experimental. Method: The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement. Results: An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time. Conclusion: Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.",

author = "Devyani Lal and Hetzler, {Laura T.} and Nijee Sharma and Wurster, {Robert D.} and Marzo, {Sam J.} and Jones, {Kathryn J.} and Foecking, {Eileen M.}",

note = "Funding Information: This work was supported by funds from the Department of Otolaryngology–Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois. The study sponsors were involved in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",

year = "2008",

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AU - Lal, Devyani

AU - Hetzler, Laura T.

AU - Sharma, Nijee

AU - Wurster, Robert D.

AU - Marzo, Sam J.

AU - Jones, Kathryn J.

AU - Foecking, Eileen M.

N1 - Funding Information: This work was supported by funds from the Department of Otolaryngology–Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois. The study sponsors were involved in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

PY - 2008/7

Y1 - 2008/7

N2 - Objective: To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model. Study Design: Experimental. Method: The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement. Results: An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time. Conclusion: Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.

AB - Objective: To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model. Study Design: Experimental. Method: The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement. Results: An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time. Conclusion: Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.

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Electrical stimulation facilitates rat facial nerve recovery from a crush injury

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