TY - GEN
T1 - Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation
AU - Kale, Rajas P.
AU - Kouzani, Abbas Z.
AU - Berk, Julian
AU - Walder, Ken
AU - Berk, Michael
AU - Tye, Susannah J.
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - The therapeutic actions of deep brain stimulation are not fully understood. The early inflammatory response of electrode implantation is associated with symptom relief without electrical stimulation, but is negated by anti-inflammatory drugs. Early excitotoxic necrosis and subsequent glial scarring modulate the conductivity of the tissue-electrode interface, which can provide some detail into the inflammatory response of individual patients. The feasibility of this was demonstrated by measuring resistance values across a bipolar electrode which was unilaterally implanted into the nucleus accumbens of a rat while receiving continuous deep brain stimulation with a portable back-mounted device using clinical parameters (130Hz, 200μ, 90μs) for 3 days. Daily resistance values rose significantly (p<0.0001), while hourly resistance analysis demonstrated a plateau after an initial spike in resistance, which was then followed by a steady increase (p<0.05; p<0.0001). We discuss that the biphasic nature of the inflammatory response may contribute to these observations and conclude that this method may translate to a safe predictive screening for more effective clinical deep brain stimulation.
AB - The therapeutic actions of deep brain stimulation are not fully understood. The early inflammatory response of electrode implantation is associated with symptom relief without electrical stimulation, but is negated by anti-inflammatory drugs. Early excitotoxic necrosis and subsequent glial scarring modulate the conductivity of the tissue-electrode interface, which can provide some detail into the inflammatory response of individual patients. The feasibility of this was demonstrated by measuring resistance values across a bipolar electrode which was unilaterally implanted into the nucleus accumbens of a rat while receiving continuous deep brain stimulation with a portable back-mounted device using clinical parameters (130Hz, 200μ, 90μs) for 3 days. Daily resistance values rose significantly (p<0.0001), while hourly resistance analysis demonstrated a plateau after an initial spike in resistance, which was then followed by a steady increase (p<0.05; p<0.0001). We discuss that the biphasic nature of the inflammatory response may contribute to these observations and conclude that this method may translate to a safe predictive screening for more effective clinical deep brain stimulation.
UR - http://www.scopus.com/inward/record.url?scp=85009083991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009083991&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2016.7591071
DO - 10.1109/EMBC.2016.7591071
M3 - Conference contribution
C2 - 28324953
AN - SCOPUS:85009083991
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1814
EP - 1817
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Y2 - 16 August 2016 through 20 August 2016
ER -