ELAVL4, PARK10, and the celts

Kristoffer Haugarvoll; Mathias Toft; Owen A. Ross; Jeremy T. Stone; Michael G. Heckman; Linda R. White; Timothy Lynch; John Mark Gibson; Zbigniew K. Wszolek; Ryan J. Uitti; Jan O. Aasly; Matthew J. Farrer

doi:10.1002/mds.21336

ELAVL4, PARK10, and the celts

Kristoffer Haugarvoll, Mathias Toft, Owen A. Ross, Jeremy T. Stone, Michael G. Heckman, Linda R. White, Timothy Lynch, John Mark Gibson, Zbigniew K. Wszolek, Ryan J. Uitti, Jan O. Aasly, Matthew J. Farrer

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

Original language	English (US)
Pages (from-to)	585-587
Number of pages	3
Journal	Movement Disorders
Volume	22
Issue number	4
DOIs	https://doi.org/10.1002/mds.21336
State	Published - Mar 15 2007

Keywords

ELAVL4
Genetics
PARK10
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/mds.21336

Cite this

@article{6d475fac4ed64fce8b26bf257ea80e19,

title = "ELAVL4, PARK10, and the celts",

abstract = "Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.",

keywords = "ELAVL4, Genetics, PARK10, Parkinson's disease",

author = "Kristoffer Haugarvoll and Mathias Toft and Ross, {Owen A.} and Stone, {Jeremy T.} and Heckman, {Michael G.} and White, {Linda R.} and Timothy Lynch and Gibson, {John Mark} and Wszolek, {Zbigniew K.} and Uitti, {Ryan J.} and Aasly, {Jan O.} and Farrer, {Matthew J.}",

year = "2007",

month = mar,

day = "15",

doi = "10.1002/mds.21336",

language = "English (US)",

volume = "22",

pages = "585--587",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - ELAVL4, PARK10, and the celts

AU - Haugarvoll, Kristoffer

AU - Toft, Mathias

AU - Ross, Owen A.

AU - Stone, Jeremy T.

AU - Heckman, Michael G.

AU - White, Linda R.

AU - Lynch, Timothy

AU - Gibson, John Mark

AU - Wszolek, Zbigniew K.

AU - Uitti, Ryan J.

AU - Aasly, Jan O.

AU - Farrer, Matthew J.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

AB - Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

KW - ELAVL4

KW - Genetics

KW - PARK10

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=34247249296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247249296&partnerID=8YFLogxK

U2 - 10.1002/mds.21336

DO - 10.1002/mds.21336

M3 - Article

C2 - 17230446

AN - SCOPUS:34247249296

SN - 0885-3185

VL - 22

SP - 585

EP - 587

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

ELAVL4, PARK10, and the celts

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this