ELAVL4, PARK10, and the celts

Kristoffer Haugarvoll, Mathias Toft, Owen A Ross, Jeremy T. Stone, Michael G. Heckman, Linda R. White, Timothy Lynch, John Mark Gibson, Zbigniew K Wszolek, Ryan J. Uitti, Jan O. Aasly, Matthew J. Farrer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalMovement Disorders
Volume22
Issue number4
DOIs
StatePublished - Mar 15 2007

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Parkinson Disease
Founder Effect
Age of Onset
Parkinson Disease 10

Keywords

  • ELAVL4
  • Genetics
  • PARK10
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Haugarvoll, K., Toft, M., Ross, O. A., Stone, J. T., Heckman, M. G., White, L. R., ... Farrer, M. J. (2007). ELAVL4, PARK10, and the celts. Movement Disorders, 22(4), 585-587. https://doi.org/10.1002/mds.21336

ELAVL4, PARK10, and the celts. / Haugarvoll, Kristoffer; Toft, Mathias; Ross, Owen A; Stone, Jeremy T.; Heckman, Michael G.; White, Linda R.; Lynch, Timothy; Gibson, John Mark; Wszolek, Zbigniew K; Uitti, Ryan J.; Aasly, Jan O.; Farrer, Matthew J.

In: Movement Disorders, Vol. 22, No. 4, 15.03.2007, p. 585-587.

Research output: Contribution to journalArticle

Haugarvoll, K, Toft, M, Ross, OA, Stone, JT, Heckman, MG, White, LR, Lynch, T, Gibson, JM, Wszolek, ZK, Uitti, RJ, Aasly, JO & Farrer, MJ 2007, 'ELAVL4, PARK10, and the celts', Movement Disorders, vol. 22, no. 4, pp. 585-587. https://doi.org/10.1002/mds.21336
Haugarvoll K, Toft M, Ross OA, Stone JT, Heckman MG, White LR et al. ELAVL4, PARK10, and the celts. Movement Disorders. 2007 Mar 15;22(4):585-587. https://doi.org/10.1002/mds.21336
Haugarvoll, Kristoffer ; Toft, Mathias ; Ross, Owen A ; Stone, Jeremy T. ; Heckman, Michael G. ; White, Linda R. ; Lynch, Timothy ; Gibson, John Mark ; Wszolek, Zbigniew K ; Uitti, Ryan J. ; Aasly, Jan O. ; Farrer, Matthew J. / ELAVL4, PARK10, and the celts. In: Movement Disorders. 2007 ; Vol. 22, No. 4. pp. 585-587.
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