ELAVL4, PARK10, and the celts

Kristoffer Haugarvoll, Mathias Toft, Owen A. Ross, Jeremy T. Stone, Michael G. Heckman, Linda R. White, Timothy Lynch, John Mark Gibson, Zbigniew K. Wszolek, Ryan J. Uitti, Jan O. Aasly, Matthew J. Farrer

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalMovement Disorders
Volume22
Issue number4
DOIs
StatePublished - Mar 15 2007

Keywords

  • ELAVL4
  • Genetics
  • PARK10
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Haugarvoll, K., Toft, M., Ross, O. A., Stone, J. T., Heckman, M. G., White, L. R., Lynch, T., Gibson, J. M., Wszolek, Z. K., Uitti, R. J., Aasly, J. O., & Farrer, M. J. (2007). ELAVL4, PARK10, and the celts. Movement Disorders, 22(4), 585-587. https://doi.org/10.1002/mds.21336