Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer

Kelvin Hong, Hisham Kobeiter, Christos S. Georgiades, Michael Torbenson, Jean Francois H. Geschwind

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (<0.079 μg/mL). CONCLUSIONS: Carboplatin concentration was significantly greater (by a factor of two to four) within the central zone of the tumor compared with the peripheral zone in both treated groups. The overall tumor carboplatin concentrations were significantly greater in the tris-acryl gelatin microsphere group than in the PVA group (P < .001), which could translate into greater potency and tumor kill. Administration of tris-acryl gelatin microspheres may be clinically advantageous during TACE, as it contributed to greater delivery of chemotherapy to tumor in the present study.

Original languageEnglish (US)
Pages (from-to)1711-1717
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Carboplatin
Liver Neoplasms
Rabbits
Liver
Neoplasms
Polyvinyl Alcohol
Sodium Chloride
Spectrum Analysis
Animal Models
Pharmacokinetics
Drug Therapy
Control Groups
trisacryl gelatin microspheres

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer. / Hong, Kelvin; Kobeiter, Hisham; Georgiades, Christos S.; Torbenson, Michael; Geschwind, Jean Francois H.

In: Journal of Vascular and Interventional Radiology, Vol. 16, No. 12, 01.12.2005, p. 1711-1717.

Research output: Contribution to journalArticle

@article{8a5c6b4e74e9485b9f7bf23ccaaefaeb,
title = "Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer",
abstract = "PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (<0.079 μg/mL). CONCLUSIONS: Carboplatin concentration was significantly greater (by a factor of two to four) within the central zone of the tumor compared with the peripheral zone in both treated groups. The overall tumor carboplatin concentrations were significantly greater in the tris-acryl gelatin microsphere group than in the PVA group (P < .001), which could translate into greater potency and tumor kill. Administration of tris-acryl gelatin microspheres may be clinically advantageous during TACE, as it contributed to greater delivery of chemotherapy to tumor in the present study.",
author = "Kelvin Hong and Hisham Kobeiter and Georgiades, {Christos S.} and Michael Torbenson and Geschwind, {Jean Francois H.}",
year = "2005",
month = "12",
day = "1",
doi = "10.1097/01.RVI.0000184535.26360.5A",
language = "English (US)",
volume = "16",
pages = "1711--1717",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer

AU - Hong, Kelvin

AU - Kobeiter, Hisham

AU - Georgiades, Christos S.

AU - Torbenson, Michael

AU - Geschwind, Jean Francois H.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (<0.079 μg/mL). CONCLUSIONS: Carboplatin concentration was significantly greater (by a factor of two to four) within the central zone of the tumor compared with the peripheral zone in both treated groups. The overall tumor carboplatin concentrations were significantly greater in the tris-acryl gelatin microsphere group than in the PVA group (P < .001), which could translate into greater potency and tumor kill. Administration of tris-acryl gelatin microspheres may be clinically advantageous during TACE, as it contributed to greater delivery of chemotherapy to tumor in the present study.

AB - PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (<0.079 μg/mL). CONCLUSIONS: Carboplatin concentration was significantly greater (by a factor of two to four) within the central zone of the tumor compared with the peripheral zone in both treated groups. The overall tumor carboplatin concentrations were significantly greater in the tris-acryl gelatin microsphere group than in the PVA group (P < .001), which could translate into greater potency and tumor kill. Administration of tris-acryl gelatin microspheres may be clinically advantageous during TACE, as it contributed to greater delivery of chemotherapy to tumor in the present study.

UR - http://www.scopus.com/inward/record.url?scp=33744751213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744751213&partnerID=8YFLogxK

U2 - 10.1097/01.RVI.0000184535.26360.5A

DO - 10.1097/01.RVI.0000184535.26360.5A

M3 - Article

C2 - 16371540

AN - SCOPUS:33744751213

VL - 16

SP - 1711

EP - 1717

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 12

ER -