TY - JOUR
T1 - Effects of Systemic Delivery of Insulin on Plasma Lipids and Lipoprotein Concentrations in Pancreas Transplant Recipients
AU - KATZ, HAROLD H.
AU - NGUYEN, TU T.
AU - VELOSA, JORGE A.
AU - ROBERTSON, R. PAUL
AU - RIZZA, ROBERT A.
N1 - Funding Information:
This study was supported in part by Grants DK 29953, DK 39994, and RR 00585 from the National Institutes of Health, Public Health Service, and by the Mayo Foundation.
PY - 1994
Y1 - 1994
N2 - To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney recipients without diabetes who received the same immunosuppressive agents, and eight normal subjects. In the three study groups, fasting and postprandial plasma glucose, insulin, C-peptide, cholesterol, triglyceride, free fatty acid, and apolipoprotein A-I, A-II, C-II, and C-III concentrations were determined. Fasting and postprandial glucose concentrations did not differ between the two transplant groups; however, peripheral insulin concentrations were twice as high (P<0.05) in the pancreas-kidney recipients as in the kidney recipients both before (102 ± 15 versus 53 ± 6 pmol/L) and after (123 ± 22 versus 61 ± 6 nmol/L per 6 hours) ingestion of a meal. Preprandial and postprandial insulin levels in both transplant groups also were greater (P<0.05) than those in normal subjects (35 ± 6 pmol/L and 40 ± 7 nmol/L per 6 hours, respectively). Despite significant differences in insulin concentrations, no differences were noted in total cholesterol, high-density or low-density lipoprotein cholesterol, plasma free fatty acids, or apolipoprotein A-I, A-II, C-II, and C-III concentrations among the study groups. Plasma triglyceride concentrations in the two transplant groups were similar (114 ± 20 versus 142 ± 18 mg/dL) and were slightly more than those in the normal subjects (80 ± 7 mg/dL). Despite peripheral hyperinsulinemia, pancreas transplantation can result in normal or near-normal lipid and lipoprotein concentrations. Thus, systemic delivery of insulin does not invariably produce an atherogenic lipid profile.
AB - To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney recipients without diabetes who received the same immunosuppressive agents, and eight normal subjects. In the three study groups, fasting and postprandial plasma glucose, insulin, C-peptide, cholesterol, triglyceride, free fatty acid, and apolipoprotein A-I, A-II, C-II, and C-III concentrations were determined. Fasting and postprandial glucose concentrations did not differ between the two transplant groups; however, peripheral insulin concentrations were twice as high (P<0.05) in the pancreas-kidney recipients as in the kidney recipients both before (102 ± 15 versus 53 ± 6 pmol/L) and after (123 ± 22 versus 61 ± 6 nmol/L per 6 hours) ingestion of a meal. Preprandial and postprandial insulin levels in both transplant groups also were greater (P<0.05) than those in normal subjects (35 ± 6 pmol/L and 40 ± 7 nmol/L per 6 hours, respectively). Despite significant differences in insulin concentrations, no differences were noted in total cholesterol, high-density or low-density lipoprotein cholesterol, plasma free fatty acids, or apolipoprotein A-I, A-II, C-II, and C-III concentrations among the study groups. Plasma triglyceride concentrations in the two transplant groups were similar (114 ± 20 versus 142 ± 18 mg/dL) and were slightly more than those in the normal subjects (80 ± 7 mg/dL). Despite peripheral hyperinsulinemia, pancreas transplantation can result in normal or near-normal lipid and lipoprotein concentrations. Thus, systemic delivery of insulin does not invariably produce an atherogenic lipid profile.
KW - HDL
KW - LDL
KW - VLDL
KW - high-density lipoprotein
KW - low-density lipoprotein
KW - very-low-density lipoprotein
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U2 - 10.1016/S0025-6196(12)61061-1
DO - 10.1016/S0025-6196(12)61061-1
M3 - Article
C2 - 8133660
AN - SCOPUS:0028281687
SN - 0025-6196
VL - 69
SP - 231
EP - 236
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 3
ER -