Effects of positive-pressure ventilation on the spontaneous baroreflex in healthy subjects

Ingo Fietze, Dietrich Romberg, Martin Glos, Susanne Endres, Heinz Theres, Christian Witt, Virend Somers

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To determine the short-term effects of noninvasive positive-pressure ventilation (PPV) on spontaneous baroreflex sensitivity, we acquired time series of R-R interval and beat-to-beat blood pressure in 55 healthy volunteers (mean age 46.5 ± 10.5 yr) who performed breathing on four occasions at frequencies of 12 and 15 breaths/min without positive pressure (control) and also using PPV of 5 mbar. By using spectral and cross-spectral analysis, R-R interval variability and systolic blood pressure variability as well as the gain (α-index) of the baroreceptor reflex were estimated for the low-frequency and high-frequency (HF) bands. Compared with control breathing, PPV at 12 breaths/min and 15 breaths/min led to an increase in mean R-R (P < 0.001) and blood pressure (P < 0.05). The α-index of the HF band increased significantly for both respiratory frequencies (P < 0.05) due to PPV. These results indicate that short-term administration of PPV in normal subjects elicits a significant enhancement in the HF index of the baroreflex gain. These findings may contribute to understanding the mechanisms, indications, and effectiveness of positive pressure breathing strategies in treating cardiorespiratory and other disease conditions.

Original languageEnglish (US)
Pages (from-to)1155-1160
Number of pages6
JournalJournal of Applied Physiology
Volume96
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Positive-Pressure Respiration
Baroreflex
Healthy Volunteers
Blood Pressure
Respiration
Pressure

Keywords

  • Baroreflex sensitivity
  • Blood pressure variability
  • Heart rate variability

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of positive-pressure ventilation on the spontaneous baroreflex in healthy subjects. / Fietze, Ingo; Romberg, Dietrich; Glos, Martin; Endres, Susanne; Theres, Heinz; Witt, Christian; Somers, Virend.

In: Journal of Applied Physiology, Vol. 96, No. 3, 03.2004, p. 1155-1160.

Research output: Contribution to journalArticle

Fietze, Ingo ; Romberg, Dietrich ; Glos, Martin ; Endres, Susanne ; Theres, Heinz ; Witt, Christian ; Somers, Virend. / Effects of positive-pressure ventilation on the spontaneous baroreflex in healthy subjects. In: Journal of Applied Physiology. 2004 ; Vol. 96, No. 3. pp. 1155-1160.
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