Abstract
We investigated the effects of MCI-154, a new inotropic agent, on tension development in saponin-skinned human trabeculae carneae. The skinned fibers were activated by buffer solutions containing varying concentrations of Ca2+ (10-8-10-4 M). In the sigmoidal tension vs. pCa (-log[Ca2+]M) relationship, the Ca2+ concentration required for half-maximal activation was shifted leftward in the presence of MCI-154. Furthermore, maximal Ca2+-activated tension development was increased in a concentration-dependent manner by MCI-154. Our results suggest that the inotropic effect of MCI-154 may be due, in part, to an increased sensitivity of the myofilaments to Ca2+ and enhancement of maximal Ca2+-activated tension development.
Original language | English (US) |
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Pages (from-to) | 305-308 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 165 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 20 1989 |
Keywords
- Imidazole
- Inotropic drugs
- MCI-154
- Myocardium (human)
- Pyridazinone
- Skinned fibers
ASJC Scopus subject areas
- Pharmacology