Effects of MCI-154 on Ca2+ activation of skinned human myocardium

Cynthia L. Perreault, Frank V. Brozovich, Bernard J. Ransil, James P. Morgan

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

We investigated the effects of MCI-154, a new inotropic agent, on tension development in saponin-skinned human trabeculae carneae. The skinned fibers were activated by buffer solutions containing varying concentrations of Ca2+ (10-8-10-4 M). In the sigmoidal tension vs. pCa (-log[Ca2+]M) relationship, the Ca2+ concentration required for half-maximal activation was shifted leftward in the presence of MCI-154. Furthermore, maximal Ca2+-activated tension development was increased in a concentration-dependent manner by MCI-154. Our results suggest that the inotropic effect of MCI-154 may be due, in part, to an increased sensitivity of the myofilaments to Ca2+ and enhancement of maximal Ca2+-activated tension development.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalEuropean Journal of Pharmacology
Volume165
Issue number2-3
DOIs
StatePublished - Jun 20 1989

Keywords

  • Imidazole
  • Inotropic drugs
  • MCI-154
  • Myocardium (human)
  • Pyridazinone
  • Skinned fibers

ASJC Scopus subject areas

  • Pharmacology

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    Perreault, C. L., Brozovich, F. V., Ransil, B. J., & Morgan, J. P. (1989). Effects of MCI-154 on Ca2+ activation of skinned human myocardium. European Journal of Pharmacology, 165(2-3), 305-308. https://doi.org/10.1016/0014-2999(89)90726-7