Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin.

C. L. Loprinzi, A. K. Verma

Research output: Contribution to journalArticle

2 Scopus citations


In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalAnticancer research
Issue number6
StatePublished - Nov 1 1984


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this