Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalAnticancer Research
Volume4
Issue number6
StatePublished - Nov 1984
Externally publishedYes

Fingerprint

Ornithine Decarboxylase
Phorbol Esters
Local Anesthetics
Skin
Tetradecanoylphorbol Acetate
Ethyl Chloride
Procaine
Local Anesthesia
Lidocaine
Biopsy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin. / Loprinzi, Charles Lawrence; Verma, A. K.

In: Anticancer Research, Vol. 4, No. 6, 11.1984, p. 363-366.

Research output: Contribution to journalArticle

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