Abstract
In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 363-366 |
| Number of pages | 4 |
| Journal | Anticancer research |
| Volume | 4 |
| Issue number | 6 |
| State | Published - Nov 1984 |
ASJC Scopus subject areas
- Oncology
- Cancer Research