In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 1 1984|
ASJC Scopus subject areas
- Cancer Research