Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS)

Mateusz Opyrchal, Cory Allen, Ianko Iankov, Ileana Aderca, Mark Schroeder, Jann Sarkaria, Evanthia Galanis

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Engineered measles virus (MV) strains deriving from the vaccine lineage represent a promising oncolytic platform and are currently being tested in phase I trials. In this study, we have demonstrated that MV strains genetically engineered to express the human sodium iodide symporter (NIS) have significant antitumor activity against glioma lines and orthotopic xenografts; this compares favorably with the MV strain expressing the human carcinoembryonic antigen, which is currently in clinical testing. Expression of NIS protein in infected cells results in effective concentration of radioactive iodine, which allows for in vivo monitoring of localization of MV-NIS infection by measuring uptake of 123I or 99mTc. In addition, radiovirotherapy with MV-NIS followed by 131I administration resulted in significant increase of MV-NIS antitumor activity as compared with virus alone in both subcutaneous (p=0.0003) and orthotopic (p=0.004) glioblastoma models. In conclusion, MV-NIS-based radiovirotherapy has significant antitumor activity against glioblastoma multiforme and represents a promising candidate for clinical translation.

Original languageEnglish (US)
Pages (from-to)419-427
Number of pages9
JournalHuman gene therapy
Volume23
Issue number4
DOIs
StatePublished - Dec 20 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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