Effect of varying surface patterns on antibiotic elution from antibiotic-loaded bone cement

Bassam A. Masri, Clive P. Duncan, Christopher P. Beauchamp, Nancy J. Paris, Jennifer Arntorp

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.

Original languageEnglish (US)
Pages (from-to)453-459
Number of pages7
JournalThe Journal of Arthroplasty
Volume10
Issue number4
DOIs
StatePublished - Aug 1995

Keywords

  • antibiotic
  • arthroplasty
  • cement
  • elution
  • infection
  • surface

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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