Abstract
In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 453-459 |
| Number of pages | 7 |
| Journal | The Journal of Arthroplasty |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- antibiotic
- arthroplasty
- cement
- elution
- infection
- surface
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
Cite this
Effect of varying surface patterns on antibiotic elution from antibiotic-loaded bone cement. / Masri, Bassam A.; Duncan, Clive P.; Beauchamp, Christopher P.; Paris, Nancy J.; Arntorp, Jennifer.
In: The Journal of Arthroplasty, Vol. 10, No. 4, 1995, p. 453-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of varying surface patterns on antibiotic elution from antibiotic-loaded bone cement
AU - Masri, Bassam A.
AU - Duncan, Clive P.
AU - Beauchamp, Christopher P.
AU - Paris, Nancy J.
AU - Arntorp, Jennifer
PY - 1995
Y1 - 1995
N2 - In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.
AB - In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.
KW - antibiotic
KW - arthroplasty
KW - cement
KW - elution
KW - infection
KW - surface
UR - http://www.scopus.com/inward/record.url?scp=0029076208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029076208&partnerID=8YFLogxK
U2 - 10.1016/S0883-5403(05)80145-7
DO - 10.1016/S0883-5403(05)80145-7
M3 - Article
C2 - 8523003
AN - SCOPUS:0029076208
VL - 10
SP - 453
EP - 459
JO - Journal of Arthroplasty
JF - Journal of Arthroplasty
SN - 0883-5403
IS - 4
ER -