Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats.

R. D. Altman, L. L. Latta, R. Keer, K. Renfree, F. J. Hornicek, K. Banovac

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

We studied the effects of two nonsteroidal antiinflammatory drugs (NSAIDs) on fracture healing in rats: ibuprofen (30 mg/kg/day) and indomethacin (1 mg/kg/day). Femoral fractures were induced via a three-point bending technique. NSAIDs were administered orally for 4 or 12 weeks. Control animals received no medication. In each group a minimum of six animals were killed at the following intervals: 2, 4, 6, 8, 10, and 12 weeks postfracture. Fracture healing was determined by mechanical testing and histologic evaluation. The bending strength of each fractured femur was expressed as a percentage of the strength of the intact, contralateral femur. Histologic evaluation was performed on serial longitudinal sections stained with hematoxylin and eosin using a qualitative score of maturity of the callus. Ibuprofen and indomethacin both retarded fracture healing, with significant differences in "mechanical healing" found between the control and experimental groups after 10 weeks of drug administration. Both drugs also induced qualitative histologic changes manifested by delayed maturation of callus, which was noticeable earlier than the difference found by mechanical testing of bone. Our data suggest that NSAIDs have an inhibitory effect on fracture repair that is reversible after cessation of indomethacin but not ibuprofen.

Original languageEnglish (US)
Pages (from-to)392-400
Number of pages9
JournalJournal of Orthopaedic Trauma
Volume9
Issue number5
StatePublished - 1995
Externally publishedYes

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Fracture Healing
Anti-Inflammatory Agents
Ibuprofen
Indomethacin
Pharmaceutical Preparations
Bony Callus
Femur
Femoral Fractures
Hematoxylin
Eosine Yellowish-(YS)
Bone and Bones
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Altman, R. D., Latta, L. L., Keer, R., Renfree, K., Hornicek, F. J., & Banovac, K. (1995). Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. Journal of Orthopaedic Trauma, 9(5), 392-400.

Effect of nonsteroidal antiinflammatory drugs on fracture healing : a laboratory study in rats. / Altman, R. D.; Latta, L. L.; Keer, R.; Renfree, K.; Hornicek, F. J.; Banovac, K.

In: Journal of Orthopaedic Trauma, Vol. 9, No. 5, 1995, p. 392-400.

Research output: Contribution to journalArticle

Altman, RD, Latta, LL, Keer, R, Renfree, K, Hornicek, FJ & Banovac, K 1995, 'Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats.', Journal of Orthopaedic Trauma, vol. 9, no. 5, pp. 392-400.
Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. Journal of Orthopaedic Trauma. 1995;9(5):392-400.
Altman, R. D. ; Latta, L. L. ; Keer, R. ; Renfree, K. ; Hornicek, F. J. ; Banovac, K. / Effect of nonsteroidal antiinflammatory drugs on fracture healing : a laboratory study in rats. In: Journal of Orthopaedic Trauma. 1995 ; Vol. 9, No. 5. pp. 392-400.
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