Effect of nanoparticle surface charge at the plasma membrane and beyond

Rochelle R. Arvizo, Oscar R. Miranda, Michael A. Thompson, Christina M Pabelick, Resham Bhattacharya, J. David Robertson, Vincent M. Rotello, Y.s. Prakash, Priyabrata Mukherjee

Research output: Contribution to journalArticle

319 Citations (Scopus)

Abstract

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Original languageEnglish (US)
Pages (from-to)2543-2548
Number of pages6
JournalNano Letters
Volume10
Issue number7
DOIs
StatePublished - Jul 14 2010

Fingerprint

Cell membranes
Surface charge
Nanoparticles
membranes
nanoparticles
cells
Membranes
biology
Gold
Modulation
interactions
engineering
gold
modulation

Keywords

  • Apoptosis
  • Calcium
  • Cancer
  • Gold nanoparticles
  • Membrane potential
  • Surface properties

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Arvizo, R. R., Miranda, O. R., Thompson, M. A., Pabelick, C. M., Bhattacharya, R., David Robertson, J., ... Mukherjee, P. (2010). Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Letters, 10(7), 2543-2548. https://doi.org/10.1021/nl101140t

Effect of nanoparticle surface charge at the plasma membrane and beyond. / Arvizo, Rochelle R.; Miranda, Oscar R.; Thompson, Michael A.; Pabelick, Christina M; Bhattacharya, Resham; David Robertson, J.; Rotello, Vincent M.; Prakash, Y.s.; Mukherjee, Priyabrata.

In: Nano Letters, Vol. 10, No. 7, 14.07.2010, p. 2543-2548.

Research output: Contribution to journalArticle

Arvizo, RR, Miranda, OR, Thompson, MA, Pabelick, CM, Bhattacharya, R, David Robertson, J, Rotello, VM, Prakash, YS & Mukherjee, P 2010, 'Effect of nanoparticle surface charge at the plasma membrane and beyond', Nano Letters, vol. 10, no. 7, pp. 2543-2548. https://doi.org/10.1021/nl101140t
Arvizo RR, Miranda OR, Thompson MA, Pabelick CM, Bhattacharya R, David Robertson J et al. Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Letters. 2010 Jul 14;10(7):2543-2548. https://doi.org/10.1021/nl101140t
Arvizo, Rochelle R. ; Miranda, Oscar R. ; Thompson, Michael A. ; Pabelick, Christina M ; Bhattacharya, Resham ; David Robertson, J. ; Rotello, Vincent M. ; Prakash, Y.s. ; Mukherjee, Priyabrata. / Effect of nanoparticle surface charge at the plasma membrane and beyond. In: Nano Letters. 2010 ; Vol. 10, No. 7. pp. 2543-2548.
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