Effect of nanoparticle surface charge at the plasma membrane and beyond

Rochelle R. Arvizo, Oscar R. Miranda, Michael A. Thompson, Christina M. Pabelick, Resham Bhattacharya, J. David Robertson, Vincent M. Rotello, Y. S. Prakash, Priyabrata Mukherjee

Research output: Contribution to journalArticlepeer-review

404 Scopus citations


Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Original languageEnglish (US)
Pages (from-to)2543-2548
Number of pages6
JournalNano Letters
Issue number7
StatePublished - Jul 14 2010


  • Apoptosis
  • Calcium
  • Cancer
  • Gold nanoparticles
  • Membrane potential
  • Surface properties

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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