Effect of nanoparticle surface charge at the plasma membrane and beyond

Rochelle R. Arvizo; Oscar R. Miranda; Michael A. Thompson; Christina M. Pabelick; Resham Bhattacharya; J. David Robertson; Vincent M. Rotello; Y. S. Prakash; Priyabrata Mukherjee

doi:10.1021/nl101140t

Effect of nanoparticle surface charge at the plasma membrane and beyond

Rochelle R. Arvizo, Oscar R. Miranda, Michael A. Thompson, Christina M. Pabelick, Resham Bhattacharya, J. David Robertson, Vincent M. Rotello, Y. S. Prakash, Priyabrata Mukherjee

Research output: Contribution to journal › Article › peer-review

404 Scopus citations

Abstract

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Original language	English (US)
Pages (from-to)	2543-2548
Number of pages	6
Journal	Nano Letters
Volume	10
Issue number	7
DOIs	https://doi.org/10.1021/nl101140t
State	Published - Jul 14 2010

Keywords

Apoptosis
Calcium
Cancer
Gold nanoparticles
Membrane potential
Surface properties

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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title = "Effect of nanoparticle surface charge at the plasma membrane and beyond",

abstract = "Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.",

keywords = "Apoptosis, Calcium, Cancer, Gold nanoparticles, Membrane potential, Surface properties",

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AU - Arvizo, Rochelle R.

AU - Miranda, Oscar R.

AU - Thompson, Michael A.

AU - Pabelick, Christina M.

AU - Bhattacharya, Resham

AU - David Robertson, J.

AU - Rotello, Vincent M.

AU - Prakash, Y. S.

AU - Mukherjee, Priyabrata

PY - 2010/7/14

Y1 - 2010/7/14

N2 - Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

AB - Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and nonmalignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

KW - Apoptosis

KW - Calcium

KW - Cancer

KW - Gold nanoparticles

KW - Membrane potential

KW - Surface properties

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JO - Nano Letters

JF - Nano Letters

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ER -

Effect of nanoparticle surface charge at the plasma membrane and beyond

Abstract

Keywords

ASJC Scopus subject areas

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