Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence

Winston W. Tan, Michael G. Heckman, Prakash Vishnu, Julia E. Crook, Linda H. Younkin, Edgar G. Covil, Tanis J. Ferman, Neill R. Graff-Radford, Steven G. Younkin, Robert C. Smallridge, Michael J. Wehle, Steven J. Buskirk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To investigate whether prostate cancer patients receiving leuprolide demonstrated objective cognitive decline accompanied by a change in plasma levels of amyloid-β. Methods: Between November 19, 2003, and July 21, 2008, we prospectively enrolled 50 patients with biochemical recurrence of prostate cancer and measured plasma amyloid-β peptide 40 and amyloid-β peptide 42 levels with sandwich enzyme-linked immunosorbent assay at baseline before the first leuprolide injection and at 2, 4, and 12 months. The Mini-Mental State Examination was used to assess 49 patients at baseline and at subsequent visits, and 24 were also assessed by the California Verbal Learning Test-Short Form. Results: Patients were a median age of 71 years (range, 59-89 years). Compared with baseline levels, plasma amyloid-β peptide 40 levels were increased at 2 months (P =.04) and 4 months (P =.02). Age was correlated with plasma amyloid-β peptide 40 levels (P =.003) and likely accounted for this relationship. Plasma amyloid-β peptide 42 and performance on cognitive tasks did not differ from baseline, but memory measures improved slightly after baseline, most likely due to a practice effect. Conclusion: Leuprolide therapy was not associated with a decline in cognition or memory function or with elevated plasma amyloid short-term. Larger studies are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalUrology
Volume81
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Urology

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