Effect of intellectual enrichment on AD biomarker trajectories

Prashanthi D Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S Knopman, Mary Margaret Machulda, Val Lowe, Michelle M Mielke, Rosebud O Roberts, Jeffrey L. Gunter, Matthew L. Senjem, Yonas Endale Geda, Walter A Rocca, Ronald Carl Petersen, Clifford R Jr. Jack

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegeneration via 18 fluorodeoxyglucose (FDG) PET and structural MRI) in an elderly population without dementia. Methods: In the population-based longitudinal Mayo Clinic Study of Aging, we studied 393 participants without dementia (340 clinically normal, 53 mild cognitive impairment; 70 years and older) who had cognitive and physical activity measures and at least 2 visits with imaging biomarkers. We dichotomized participants into high (≥14 years) and low (

Original languageEnglish (US)
Pages (from-to)1128-1135
Number of pages8
JournalNeurology
Volume86
Issue number12
DOIs
StatePublished - Mar 22 2016

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Dementia
Alzheimer Disease
Biomarkers
Exercise
Occupations
Amyloid
Neuroimaging
Population
Life Style
Genotype
Education
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Cognitive Dysfunction

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Effect of intellectual enrichment on AD biomarker trajectories. / Vemuri, Prashanthi D; Lesnick, Timothy G.; Przybelski, Scott A.; Knopman, David S; Machulda, Mary Margaret; Lowe, Val; Mielke, Michelle M; Roberts, Rosebud O; Gunter, Jeffrey L.; Senjem, Matthew L.; Geda, Yonas Endale; Rocca, Walter A; Petersen, Ronald Carl; Jack, Clifford R Jr.

In: Neurology, Vol. 86, No. 12, 22.03.2016, p. 1128-1135.

Research output: Contribution to journalArticle

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AU - Lesnick, Timothy G.

AU - Przybelski, Scott A.

AU - Knopman, David S

AU - Machulda, Mary Margaret

AU - Lowe, Val

AU - Mielke, Michelle M

AU - Roberts, Rosebud O

AU - Gunter, Jeffrey L.

AU - Senjem, Matthew L.

AU - Geda, Yonas Endale

AU - Rocca, Walter A

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

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