Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats

R. A. Rizza, M. F. Crass, J. C. Shipp

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalMetabolism
Volume20
Issue number6
DOIs
StatePublished - Jun 1971

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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