The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism