Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats

R. A. Rizza; M. F. Crass; J. C. Shipp

doi:10.1016/0026-0495(71)90002-3

Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats

R. A. Rizza, M. F. Crass, J. C. Shipp

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.

Original language	English (US)
Pages (from-to)	539-543
Number of pages	5
Journal	Metabolism
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/0026-0495(71)90002-3
State	Published - Jun 1971

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/0026-0495(71)90002-3

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title = "Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats",

abstract = "The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.",

author = "Rizza, {R. A.} and Crass, {M. F.} and Shipp, {J. C.}",

note = "Funding Information: From the Department of Medicine, University of Florida College of Medicine, Gaines-I*ille, Fla. Received for publication February I, 1971. Supported by USPHS Grants AM4829, AM5444, and F&2. R. A. RIZZA: Medical Student, University of Florida College of Medicine, Gainesville, Fla. M, F. CRASS, III, PH.D.: Departments of Biochemistry and of Medicine, University of Nebraska Medical Center, Omaha, Nebr. J. C. SHIPP, M.D.: Department of Medicine, University of Nebraska Medical Center, Omaha, Nebr.",

year = "1971",

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doi = "10.1016/0026-0495(71)90002-3",

language = "English (US)",

volume = "20",

pages = "539--543",

journal = "Metabolism",

issn = "0026-0495",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats

AU - Rizza, R. A.

AU - Crass, M. F.

AU - Shipp, J. C.

N1 - Funding Information: From the Department of Medicine, University of Florida College of Medicine, Gaines-I*ille, Fla. Received for publication February I, 1971. Supported by USPHS Grants AM4829, AM5444, and F&2. R. A. RIZZA: Medical Student, University of Florida College of Medicine, Gainesville, Fla. M, F. CRASS, III, PH.D.: Departments of Biochemistry and of Medicine, University of Nebraska Medical Center, Omaha, Nebr. J. C. SHIPP, M.D.: Department of Medicine, University of Nebraska Medical Center, Omaha, Nebr.

PY - 1971/6

Y1 - 1971/6

N2 - The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.

AB - The effect of insulin treatment in vivo on cardiac glycerides and glycogen was studied in alloxan-diabetic rats. In untreated alloxan-diabetic rats, heart glycerides and glycogen were increased two- to threefold. The increase in heart glycerides and glycogen and in concentrations of serum FFA were maximal 36 hr after alloxan; serum glucose continued to rise through 48 hr. Insulin, started 24-hr postalloxan, restored heart glycerides to control values within 12 hr and reduced heart glycogen content and serum glucose and FFA concentrations. Heart glycogen and serum FFA were normal 24 hr after insulin treatment.

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JO - Metabolism

JF - Metabolism

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ER -

Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats

Abstract

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