Effect of hyaluronic acid on the excursion resistance of tendon graft: A biomechanical in vitro study in a modified human model

Toshiki Akasaka, Jun Nishida, Toshihiko Imaeda, Tadashi Shimamura, Peter C Amadio, Kai Nan An

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Adhesion between the tendon and tendon sheath after flexor tendon graft inhibits restoration of excursion and strength of the grafted tendons, so post-operative finger function is occasionally unsatisfactory. Early setting rehabilitation is one important factor to prevent the adhesion, and another factor may be a lubricant. We considered the possibility of utilizing hyaluronic acid as a lubricant. The goal of this study is to investigate the in vitro effect of hyaluronic acid on tendon excursion resistance against a digital pulley in a modified human model. Methods: The excursion resistance between grafted intrasynovial and extrasynovial tendons and A2 pulley were evaluated, and compared before and after soaking in 10 mg/ml hyaluronic acid. Findings: The resistance increased after extrasynovial tendon graft, and then it decreased after soaking hyaluronic acid solution. Interpretation: The evidence we collected suggests that some style of administration of the hyaluronic acid might reduce the excursion resistance in the tendon-pulley unit, facilitating post-operative rehabilitation and limiting adhesion, after tendon graft and possibly improve the clinical outcome of flexor tendon graft.

Original languageEnglish (US)
Pages (from-to)810-815
Number of pages6
JournalClinical Biomechanics
Volume21
Issue number8
DOIs
StatePublished - Oct 2006

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Hyaluronic Acid
Tendons
Transplants
Lubricants
Rehabilitation
In Vitro Techniques
varespladib methyl
Fingers

Keywords

  • Friction
  • Hyaluronic acid
  • Lubricant
  • Tendon-pulley unit

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Effect of hyaluronic acid on the excursion resistance of tendon graft : A biomechanical in vitro study in a modified human model. / Akasaka, Toshiki; Nishida, Jun; Imaeda, Toshihiko; Shimamura, Tadashi; Amadio, Peter C; An, Kai Nan.

In: Clinical Biomechanics, Vol. 21, No. 8, 10.2006, p. 810-815.

Research output: Contribution to journalArticle

Akasaka, Toshiki ; Nishida, Jun ; Imaeda, Toshihiko ; Shimamura, Tadashi ; Amadio, Peter C ; An, Kai Nan. / Effect of hyaluronic acid on the excursion resistance of tendon graft : A biomechanical in vitro study in a modified human model. In: Clinical Biomechanics. 2006 ; Vol. 21, No. 8. pp. 810-815.
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