Effect of general anesthesia in patients with cerebral palsy at the turn of the new millennium: A population-based study evaluating perioperative outcome and brief overview of anesthetic implications of this coexisting disease

C. Thomas Wass, Mary E. Warner, Gregory A. Worrell, Julie A. Castagno, Melinda Howe, Kimberly A. Kerber, Jenna M. Palzkill, Darrell R. Schroeder, Gregory D. Cascino

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

The severity of preoperative cerebral palsy appears to correlate directly with postoperative complications. The primary aim of this study was to characterize the frequency of perioperative morbidity and mortality in cerebral palsy patients undergoing anesthesia. This was accomplished by undertaking a systematic review of the Mayo Database. The risk for perioperative adverse events was 63.1% (95% confidence interval 59.8%-66.5%). However, it deserves clarification that hypothermia and clinically significant yet non-life-threatening hypotension represented the majority (80%) of these complications. When these 2 events are excluded, the rate of adverse perioperative events was 13.1% (95% confidence interval 10.8%-15.5%). Risk factors associated with increased risk included American Society of Anesthesiologists physical status score exceeding 2, history of seizures, upper airway hypotonia, general surgery procedures, and adults. Our findings are useful to counsel patients with cerebral palsy, their caregivers, and their guardians regarding the risk of general anesthesia.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalJournal of child neurology
Volume27
Issue number7
DOIs
StatePublished - Jul 2012

Keywords

  • Cerebral palsy
  • General anesthesia
  • Morbidity
  • Outcome
  • Perioperative

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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