Effect of enteric nonnutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum

Kevin E. Behrns, Michael G. Sarr, Russell B. Hanson, Joanne T. Benson, Alan R. Zinsmeister

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous work in our laboratory has shown that nonnutrient mechanical factors initiate changes in motility patterns in local and remote regions of the small intestine. Our aims were to determine how isolated duodenal and jejunoileal nonnutrient infusions alter interdigestive motor patterns locally and distantly and whether these effects are neurally mediated. Ten dogs were prepared with duodenal and proximal jejunal infusion and manometry catheters and a proximal jejunal diverting cannula. Five of these dogs served as neurally intact controls (Group 1) and five also underwent in situ neural isolation of the entire jejunoileum (Group 2: extrinsic denervation; disruption of enteric myoneural continuity with duodenum). After recovery, nonnutrient infusions at 0 - 15 ml/min for 5 hr into proximal duodenum or jejunum did not consistently affect cycling of the migrating motor complex (MMC). The period and duration of individual phases of the MMC and time to first phase III after the start of infusion were similar in both groups. In Group 2, duodenal characteristics (period and duration of phase II, time to first phase III) increased slightly with increasing rates of jejunal but not duodenal infusion. Motility indices, although greater in Group 2, were not altered by enteric infusions. Differing rates of nonnutrient enteric flow limited to duodenum or jejunoileum did not affect markedly local or distant motor patterns. Alterations in interdigestive motility patterns by postprandial nonnutrient intraluminal content are not mediated directly by intraluminal flow.

Original languageEnglish (US)
Pages (from-to)405-414
Number of pages10
JournalJournal of Surgical Research
Volume59
Issue number3
DOIs
StatePublished - 1995

Fingerprint

Jejunum
Duodenum
Migrating Myoelectric Complexes
Canidae
Dogs
Manometry
Denervation
Small Intestine
Catheters
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of enteric nonnutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum. / Behrns, Kevin E.; Sarr, Michael G.; Hanson, Russell B.; Benson, Joanne T.; Zinsmeister, Alan R.

In: Journal of Surgical Research, Vol. 59, No. 3, 1995, p. 405-414.

Research output: Contribution to journalArticle

Behrns, Kevin E. ; Sarr, Michael G. ; Hanson, Russell B. ; Benson, Joanne T. ; Zinsmeister, Alan R. / Effect of enteric nonnutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum. In: Journal of Surgical Research. 1995 ; Vol. 59, No. 3. pp. 405-414.
@article{6815e28dbf1a40d7afa1100e3cb721ac,
title = "Effect of enteric nonnutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum",
abstract = "Previous work in our laboratory has shown that nonnutrient mechanical factors initiate changes in motility patterns in local and remote regions of the small intestine. Our aims were to determine how isolated duodenal and jejunoileal nonnutrient infusions alter interdigestive motor patterns locally and distantly and whether these effects are neurally mediated. Ten dogs were prepared with duodenal and proximal jejunal infusion and manometry catheters and a proximal jejunal diverting cannula. Five of these dogs served as neurally intact controls (Group 1) and five also underwent in situ neural isolation of the entire jejunoileum (Group 2: extrinsic denervation; disruption of enteric myoneural continuity with duodenum). After recovery, nonnutrient infusions at 0 - 15 ml/min for 5 hr into proximal duodenum or jejunum did not consistently affect cycling of the migrating motor complex (MMC). The period and duration of individual phases of the MMC and time to first phase III after the start of infusion were similar in both groups. In Group 2, duodenal characteristics (period and duration of phase II, time to first phase III) increased slightly with increasing rates of jejunal but not duodenal infusion. Motility indices, although greater in Group 2, were not altered by enteric infusions. Differing rates of nonnutrient enteric flow limited to duodenum or jejunoileum did not affect markedly local or distant motor patterns. Alterations in interdigestive motility patterns by postprandial nonnutrient intraluminal content are not mediated directly by intraluminal flow.",
author = "Behrns, {Kevin E.} and Sarr, {Michael G.} and Hanson, {Russell B.} and Benson, {Joanne T.} and Zinsmeister, {Alan R.}",
year = "1995",
doi = "10.1006/jsre.1995.1183",
language = "English (US)",
volume = "59",
pages = "405--414",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Effect of enteric nonnutrient infusions on motor patterns in neurally intact and neurally isolated canine jejunum

AU - Behrns, Kevin E.

AU - Sarr, Michael G.

AU - Hanson, Russell B.

AU - Benson, Joanne T.

AU - Zinsmeister, Alan R.

PY - 1995

Y1 - 1995

N2 - Previous work in our laboratory has shown that nonnutrient mechanical factors initiate changes in motility patterns in local and remote regions of the small intestine. Our aims were to determine how isolated duodenal and jejunoileal nonnutrient infusions alter interdigestive motor patterns locally and distantly and whether these effects are neurally mediated. Ten dogs were prepared with duodenal and proximal jejunal infusion and manometry catheters and a proximal jejunal diverting cannula. Five of these dogs served as neurally intact controls (Group 1) and five also underwent in situ neural isolation of the entire jejunoileum (Group 2: extrinsic denervation; disruption of enteric myoneural continuity with duodenum). After recovery, nonnutrient infusions at 0 - 15 ml/min for 5 hr into proximal duodenum or jejunum did not consistently affect cycling of the migrating motor complex (MMC). The period and duration of individual phases of the MMC and time to first phase III after the start of infusion were similar in both groups. In Group 2, duodenal characteristics (period and duration of phase II, time to first phase III) increased slightly with increasing rates of jejunal but not duodenal infusion. Motility indices, although greater in Group 2, were not altered by enteric infusions. Differing rates of nonnutrient enteric flow limited to duodenum or jejunoileum did not affect markedly local or distant motor patterns. Alterations in interdigestive motility patterns by postprandial nonnutrient intraluminal content are not mediated directly by intraluminal flow.

AB - Previous work in our laboratory has shown that nonnutrient mechanical factors initiate changes in motility patterns in local and remote regions of the small intestine. Our aims were to determine how isolated duodenal and jejunoileal nonnutrient infusions alter interdigestive motor patterns locally and distantly and whether these effects are neurally mediated. Ten dogs were prepared with duodenal and proximal jejunal infusion and manometry catheters and a proximal jejunal diverting cannula. Five of these dogs served as neurally intact controls (Group 1) and five also underwent in situ neural isolation of the entire jejunoileum (Group 2: extrinsic denervation; disruption of enteric myoneural continuity with duodenum). After recovery, nonnutrient infusions at 0 - 15 ml/min for 5 hr into proximal duodenum or jejunum did not consistently affect cycling of the migrating motor complex (MMC). The period and duration of individual phases of the MMC and time to first phase III after the start of infusion were similar in both groups. In Group 2, duodenal characteristics (period and duration of phase II, time to first phase III) increased slightly with increasing rates of jejunal but not duodenal infusion. Motility indices, although greater in Group 2, were not altered by enteric infusions. Differing rates of nonnutrient enteric flow limited to duodenum or jejunoileum did not affect markedly local or distant motor patterns. Alterations in interdigestive motility patterns by postprandial nonnutrient intraluminal content are not mediated directly by intraluminal flow.

UR - http://www.scopus.com/inward/record.url?scp=0029130109&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029130109&partnerID=8YFLogxK

U2 - 10.1006/jsre.1995.1183

DO - 10.1006/jsre.1995.1183

M3 - Article

VL - 59

SP - 405

EP - 414

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 3

ER -