Effect of cholecystokinin octapeptide and atropine on human colonic motility, tone, and transit

Michael D. O'Brien, Michael Camilleri, George M. Thomforde, Julie A. Wiste, Russell B. Hanson, Alan R. Zinsmeister

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The role of cholecystokinin (CCK) in postprandial control of colonic motility is controversial. To test the hypothesis that CCK stimulates colonic tone, motility, and transit we measured these colonic functions in 16 healthy subjects using intraluminal manometry, barostatic balloon measurements, and radioscintigraphy. This was a randomized-order, double-blind, sequential study design in each subject of saline and either atropine (0.01 mg/kg stat and 0.01 mg/kg/hr by infusion) or CCK-octapeptide (OP, 30 ng/kg stat and 60 ng/kg/hr by infusion). Atropine was used as control to demonstrate responsiveness of selected parameters of colonic motility. Atropine significantly reduced whole colon (change from fasting = 52 ± 11%) and left colon (change from fasting 61 ± 8%) phasic pressure activity and transverse colon tone (change from fasting 159 ± 40%); CCK-OP had no significant effects on phasic contractility, tone or transit. Thus, a CCK-OP infusion that maximally stimulates pancreatic exocrine secretion and gallbladder contraction has no effect on motor function or transit in prepared colon of healthy subjects.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalDigestive Diseases and Sciences
Volume42
Issue number1
DOIs
StatePublished - 1997

Fingerprint

Sincalide
Cholecystokinin
Atropine
Fasting
Colon
Healthy Volunteers
Transverse Colon
Manometry
Gallbladder
Double-Blind Method
Pressure

Keywords

  • atropine
  • cholecystokinin
  • gastrocolonic tone
  • motility
  • transit

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of cholecystokinin octapeptide and atropine on human colonic motility, tone, and transit. / O'Brien, Michael D.; Camilleri, Michael; Thomforde, George M.; Wiste, Julie A.; Hanson, Russell B.; Zinsmeister, Alan R.

In: Digestive Diseases and Sciences, Vol. 42, No. 1, 1997, p. 26-33.

Research output: Contribution to journalArticle

O'Brien, Michael D. ; Camilleri, Michael ; Thomforde, George M. ; Wiste, Julie A. ; Hanson, Russell B. ; Zinsmeister, Alan R. / Effect of cholecystokinin octapeptide and atropine on human colonic motility, tone, and transit. In: Digestive Diseases and Sciences. 1997 ; Vol. 42, No. 1. pp. 26-33.
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