Abstract
Increased basal epicardial tone may attenuate the coronary flow reserve (CFR) by causing vasodilatation of resistance vessels. We examined the effect of basal epicardial tone on the endothelium-independent CFR measurements in subjects with nonobstructive coronary disease. Patients underwent evaluation of endothelium-independent CFR using adenosine (18-36 μg) and endothelium- dependent CFR using acetylcholine (10-6M-10-4M), both administered intracoronary. CFR to adenosine, presented as the ratio of Doppler flow velocities post- and pre-adenosine, was measured at baseline and after intracoronary nitroglycerin (200 μg). Nitroglycerin increased the coronary artery diameter by 19.7 ± 2.5%, and decreased the coronary vascular resistance from 3.0 ± 0.2 mm Hg/ml/min to 1.8 ± 0.1 mm Hg/ml/min (p < 0.0001). The response to adenosine at baseline and after nitroglycerin was similar (CFR ratio of 2.52 ± 0.09 and 2.57 ± 0.10, respectively, p = NS). The effect of nitroglycerin on the response to adenosine did not correlate with coronary endothelial function (r2 = 0.06, p = 0.13). The basal epicardial tone does not affect CFR measurements in patients with angina and nonobstructive coronary disease.
Original language | English (US) |
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Pages (from-to) | 392-396 |
Number of pages | 5 |
Journal | Catheterization and cardiovascular diagnosis |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1998 |
Keywords
- Acetylcholine
- Adenosine
- Coronary artery disease
- Coronary flow reserve
- Doppler
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine