TY - JOUR
T1 - Effect of age on the presence of comet tails at high altitude
AU - Coffman, Kirsten E.
AU - Stewart, Glenn M.
AU - Carlson, Alex R.
AU - Wheatley, Courtney M.
AU - Johnson, Bruce D.
N1 - Funding Information:
This study was funded by Thorne Research , a research fund by the late Dr. Paul Magelli who was a long time faculty member of the University of Illinois Business School, and Philips. KEC was supported by Mayo Clinic Graduate School of Biomedical Sciences and NIH grant F31HL131076 .
Funding Information:
This study was funded by Thorne Research, a research fund by the late Dr. Paul Magelli who was a long time faculty member of the University of Illinois Business School, and Philips. KEC was supported by Mayo Clinic Graduate School of Biomedical Sciences and NIH grant F31HL131076.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1
Y1 - 2019/1
N2 - Extravascular lung water (EVLW) increases in healthy adults upon exposure to high altitude, likely due to increased pulmonary vascular resistance (PVR). Older individuals experience increased PVR during exercise, which may be exacerbated by trekking at high altitude. This study aimed to determine whether EVLW development is greater in older versus younger adults during graded altitude exposure. Fourteen younger (32 ± 6y) and 12 older (58 ± 5y) healthy adults completed an 11-day trek of Mount Kilimanjaro. EVLW was assessed at rest via comet tails prior to the trek in Moshi (950 m), at Shira Camp (3505 m), at Barafu Camp (4837 m), and post-descent. An increase in altitude from Baseline to Barafu tended to increase the proportion of participants with mild EVLW (p = 0.06). A higher proportion of older versus younger individuals tended to show mild EVLW at Barafu (56 vs. 14%, p = 0.06). In conclusion, EVLW formation may be more common in older adults trekking at high altitude. However, the presence of EVLW in older adults was subclinical.
AB - Extravascular lung water (EVLW) increases in healthy adults upon exposure to high altitude, likely due to increased pulmonary vascular resistance (PVR). Older individuals experience increased PVR during exercise, which may be exacerbated by trekking at high altitude. This study aimed to determine whether EVLW development is greater in older versus younger adults during graded altitude exposure. Fourteen younger (32 ± 6y) and 12 older (58 ± 5y) healthy adults completed an 11-day trek of Mount Kilimanjaro. EVLW was assessed at rest via comet tails prior to the trek in Moshi (950 m), at Shira Camp (3505 m), at Barafu Camp (4837 m), and post-descent. An increase in altitude from Baseline to Barafu tended to increase the proportion of participants with mild EVLW (p = 0.06). A higher proportion of older versus younger individuals tended to show mild EVLW at Barafu (56 vs. 14%, p = 0.06). In conclusion, EVLW formation may be more common in older adults trekking at high altitude. However, the presence of EVLW in older adults was subclinical.
KW - Acclimatization
KW - B-lines
KW - Exercise
KW - Extravascular lung water
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U2 - 10.1016/j.resp.2018.07.010
DO - 10.1016/j.resp.2018.07.010
M3 - Article
C2 - 30056244
AN - SCOPUS:85051409085
SN - 1569-9048
VL - 259
SP - 166
EP - 169
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -