Economic analysis of combined endoscopic and endobronchial ultrasound in the evaluation of patients with suspected non-small cell lung cancer

Gavin C. Harewood, Jorge Pascual, Massimo Raimondo, Timothy Woodward, Margaret Johnson, Barbara McComb, John Odell, Laith H. Jamil, Kanwar Rupinder S Gill, Michael B Wallace

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Lung cancer remains the most common cause of cancer-related death in the United States. This study evaluated the costs of alternative diagnostic evaluations for patients with suspected non-small cell lung cancer (NSCLC). Researchers used a cost-minimization model to compare various diagnostic approaches in the evaluation of patients with NSCLC. It was less expensive to use an initial endoscopic ultrasound (EUS) with fine needle aspiration (FNA) to detect a mediastinal lymph node metastasis ($18,603 per patient), compared with combined EUS FNA and endobronchial ultrasound (EBUS) with FNA ($18,753). The results were sensitive to the prevalence of malignant mediastinal lymph nodes; EUS FNA remained least costly, if the probability of nodal metastases was <32.9%, as would occur in a patient without abnormal lymph nodes on computed tomography (CT). While EUS FNA combined with EBUS FNA was the most economical approach, if the rate of nodal metastases was higher, as would be the case in patients with abnormal lymph nodes on CT. Both of these strategies were less costly than bronchoscopy or mediastinoscopy. The pre-test probability of nodal metastases can determine the most cost-effective testing strategy for evaluation of a patient with NSCLC. Pre-procedure CT may be helpful in assessing probability of mediastinal nodal metastases.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalLung Cancer
Volume67
Issue number3
DOIs
StatePublished - Mar 2010

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Fine Needle Biopsy
Non-Small Cell Lung Carcinoma
Economics
Neoplasm Metastasis
Lymph Nodes
Tomography
Costs and Cost Analysis
Mediastinoscopy
Bronchoscopy
Lung Neoplasms
Research Personnel
Neoplasms

Keywords

  • Endobronchial ultrasound
  • Medical economics
  • Non-small cell lung cancer
  • Ultrasonography

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Economic analysis of combined endoscopic and endobronchial ultrasound in the evaluation of patients with suspected non-small cell lung cancer. / Harewood, Gavin C.; Pascual, Jorge; Raimondo, Massimo; Woodward, Timothy; Johnson, Margaret; McComb, Barbara; Odell, John; Jamil, Laith H.; Gill, Kanwar Rupinder S; Wallace, Michael B.

In: Lung Cancer, Vol. 67, No. 3, 03.2010, p. 366-371.

Research output: Contribution to journalArticle

Harewood, Gavin C. ; Pascual, Jorge ; Raimondo, Massimo ; Woodward, Timothy ; Johnson, Margaret ; McComb, Barbara ; Odell, John ; Jamil, Laith H. ; Gill, Kanwar Rupinder S ; Wallace, Michael B. / Economic analysis of combined endoscopic and endobronchial ultrasound in the evaluation of patients with suspected non-small cell lung cancer. In: Lung Cancer. 2010 ; Vol. 67, No. 3. pp. 366-371.
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