Early salvage radiation therapy post-prostatectomy: Key considerations

Alessandro Morlacco, Robert Jeffrey Karnes

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Post-prostatectomy radiotherapy (RT) is commonly employed to maximize oncologic outcomes in patients with pathologic adverse features (adjuvant RT]) or to treat men with prostate-specific antigen or local recurrence after initial observation (salvage RT [SRT]). Randomized controlled trials have been unable to compare adjuvant RT versus SRT; however, there is growing retrospective evidence that observation and early SRT (eSRT) may be a suitable. The issue of patient selection is crucial; several clinical tools and some newer biomarker-based tools might help in this process. Moreover, the optimal prostate-specific antigen threshold for eSRT, the RT dose, the irradiation field and the use of hormonal therapy are still open questions. In this article, we review the current literature on eSRT and provide some insights on what's happening for the future.

Original languageEnglish (US)
Pages (from-to)2579-2587
Number of pages9
JournalFuture Oncology
Volume12
Issue number22
DOIs
StatePublished - Nov 1 2016

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Keywords

  • adjuvant
  • biomarkers
  • early salvage
  • predictive models
  • prostate cancer
  • prostatectomy
  • radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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