Dynamic imaging of ictal oscillations using non-invasive high-resolution EEG

Lin Yang, Christopher Wilke, Benjamin Brinkmann, Gregory Alan Worrell, Bin He

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Scalp electroencephalography (EEG) has been established as a major component of the pre-surgical evaluation for epilepsy surgery. However, its ability to localize seizure onset zones (SOZ) has been significantly restricted by its low spatial resolution and indirect correlation with underlying brain activities. Here we report a novel non-invasive dynamic seizure imaging (DSI) approach based upon high-density EEG recordings. This novel approach was particularly designed to image the dynamic changes of ictal rhythmic discharges that evolve through time, space and frequency. This method was evaluated in a group of 8 epilepsy patients and results were rigorously validated using intracranial EEG (iEEG) (n = 3) and surgical outcome (n = 7). The DSI localized the ictal activity in concordance with surgically resected zones and ictal iEEG recordings in the cohort of patients. The present promising results support the ability to precisely and accurately image dynamic seizure activity from non-invasive measurements. The successful establishment of such a non-invasive seizure imaging modality for surgical evaluation will have a significant impact in the management of medically intractable epilepsy.

Original languageEnglish (US)
Pages (from-to)1908-1917
Number of pages10
JournalNeuroImage
Volume56
Issue number4
DOIs
StatePublished - Jun 15 2011

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Electroencephalography
Seizures
Stroke
Epilepsy
Scalp
Brain
Electrocorticography

Keywords

  • Dynamic seizure imaging
  • High-resolution EEG
  • Pre-surgical planning

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Dynamic imaging of ictal oscillations using non-invasive high-resolution EEG. / Yang, Lin; Wilke, Christopher; Brinkmann, Benjamin; Worrell, Gregory Alan; He, Bin.

In: NeuroImage, Vol. 56, No. 4, 15.06.2011, p. 1908-1917.

Research output: Contribution to journalArticle

Yang, Lin ; Wilke, Christopher ; Brinkmann, Benjamin ; Worrell, Gregory Alan ; He, Bin. / Dynamic imaging of ictal oscillations using non-invasive high-resolution EEG. In: NeuroImage. 2011 ; Vol. 56, No. 4. pp. 1908-1917.
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