Dual inhibition of MEK and PI3K/Akt rescues cancer cachexia through both tumor-extrinsic and -intrinsic activities

Erin E. Talbert, Jennifer Yang, Thomas A. Mace, Matthew R. Farren, Alton B. Farris, Gregory S. Young, Omar Elnaggar, Zheng Che, Cynthia D. Timmers, Priyani Rajasekera, Jennifer M. Maskarinec, Mark Bloomston, Tanios Bekaii-Saab, Denis C. Guttridge, Gregory B. Lesinski

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Medicine & Life Sciences