Drosophila strain specific response to cisplatin neurotoxicity

Christopher M. Groen, Jewel L. Podratz, Kevin Treb, Anthony John Windebank

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.

Original languageEnglish (US)
JournalFly
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • ABC transporter
  • chemotherapy-induced peripheral neuropathy
  • cisplatin
  • Drosophila
  • glutathione
  • neurodegeneration

ASJC Scopus subject areas

  • Insect Science

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