Abstract
Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.
Original language | English (US) |
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Pages (from-to) | 174-182 |
Number of pages | 9 |
Journal | Fly |
Volume | 12 |
Issue number | 3-4 |
DOIs | |
State | Published - Oct 2 2018 |
Keywords
- ABC transporter
- Drosophila
- chemotherapy-induced peripheral neuropathy
- cisplatin
- glutathione
- neurodegeneration
ASJC Scopus subject areas
- Insect Science