TY - JOUR
T1 - Donor Scoring System for Cadaveric Renal Transplantation
AU - Nyberg, Scott L.
AU - Matas, Arthur J.
AU - Rogers, Margaret
AU - Harmsen, William S.
AU - Velosa, Jorge A.
AU - Larson, Timothy S.
AU - Prieto, Mikel
AU - Ishitani, Michael B.
AU - Sterioff, Sylvester
AU - Stegall, Mark D.
PY - 2001/7
Y1 - 2001/7
N2 - We studied early renal function in 241 consecutive patients who received cadaveric renal transplants at two different transplantation centers (group 1, n=90; group 2, n=151). Univariate and multivariate analyses of data from group 1 showed a significant correlation between seven donor variables and early renal function after cadaveric renal transplantation. A scoring system was developed from these seven donor variables (cause of death, 0-6 points; history of hypertension, 0-6; final creatinine clearance before procurement, 0-6; age, 0-6; history of diabetes mellitus, 0-3; cold ischemia time, 0-3; and severity of renal artery plaque, 0-3). Data from group 2 were used to validate the donor scoring system and stratify cadaver kidneys on the basis of score: grade A, 0-5 points; grade B, 6-10; grade C, 11-15; and grade D, 16-32. A significant decline in early renal function was observed with increasing donor score and grade of cadaver kidney. In conclusion, a donor scoring system based on information available at the time of procurement can be used to estimate early graft function after cadaveric renal transplantation and may assist in the allocation of marginal organs.
AB - We studied early renal function in 241 consecutive patients who received cadaveric renal transplants at two different transplantation centers (group 1, n=90; group 2, n=151). Univariate and multivariate analyses of data from group 1 showed a significant correlation between seven donor variables and early renal function after cadaveric renal transplantation. A scoring system was developed from these seven donor variables (cause of death, 0-6 points; history of hypertension, 0-6; final creatinine clearance before procurement, 0-6; age, 0-6; history of diabetes mellitus, 0-3; cold ischemia time, 0-3; and severity of renal artery plaque, 0-3). Data from group 2 were used to validate the donor scoring system and stratify cadaver kidneys on the basis of score: grade A, 0-5 points; grade B, 6-10; grade C, 11-15; and grade D, 16-32. A significant decline in early renal function was observed with increasing donor score and grade of cadaver kidney. In conclusion, a donor scoring system based on information available at the time of procurement can be used to estimate early graft function after cadaveric renal transplantation and may assist in the allocation of marginal organs.
KW - Delayed graft function
KW - Marginal donor
KW - Organ allocation
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U2 - 10.1034/j.1600-6143.2001.10211.x
DO - 10.1034/j.1600-6143.2001.10211.x
M3 - Article
C2 - 12099365
AN - SCOPUS:0035401121
SN - 1600-6135
VL - 1
SP - 162
EP - 170
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 2
ER -