Does the ileocolonic junction differentiate between solids and liquids?

J. Hammer, Michael Camilleri, S. F. Phillips, A. Aggarwal, A. M. Haddad

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Previous observations from our laboratory have suggested that colonic filling from the ileum is characterised by a series of bolus movements. The present experiments were designed to test the hypothesis that bolus transit of ileal contents into the colon would not distinguish between solids and liquids. After a manometric infusion assembly was positioned by mouth into the ileum of 13 healthy volunteers, a mixture of nutrients (75 kcal), incorporating a solid phase radiolabel ( 111In labelled resin pellets) and a liquid phase marker ( 99mTc-DTPA), was infused into the ileum. Transit of both labels from the ileum to colon was quantified scintigraphically and ileal motility was also recorded. When markers were infused into the proximal ileum, 100 cm proximal to the ileocolonic junction (six), there were clear cut examples of discriminant transit, when liquids moved more rapidly from the small to the large bowel than did solids. When isotopes were instilled into the distal ileum, less than 50 cm from the ileocolonic junction, no separate transit of the solid and liquid phases was observed. No specific motor pattern of the ileum was regularly associated with bolus filling of the colon. These results support the hypothesis that the distal ileum can discriminate between solids and liquids but that the ileocecal junction cannot.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalGut
Volume34
Issue number2
StatePublished - 1993

Fingerprint

Ileum
Colon
Pentetic Acid
Isotopes
Mouth
Healthy Volunteers
Food

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hammer, J., Camilleri, M., Phillips, S. F., Aggarwal, A., & Haddad, A. M. (1993). Does the ileocolonic junction differentiate between solids and liquids? Gut, 34(2), 222-226.

Does the ileocolonic junction differentiate between solids and liquids? / Hammer, J.; Camilleri, Michael; Phillips, S. F.; Aggarwal, A.; Haddad, A. M.

In: Gut, Vol. 34, No. 2, 1993, p. 222-226.

Research output: Contribution to journalArticle

Hammer, J, Camilleri, M, Phillips, SF, Aggarwal, A & Haddad, AM 1993, 'Does the ileocolonic junction differentiate between solids and liquids?', Gut, vol. 34, no. 2, pp. 222-226.
Hammer J, Camilleri M, Phillips SF, Aggarwal A, Haddad AM. Does the ileocolonic junction differentiate between solids and liquids? Gut. 1993;34(2):222-226.
Hammer, J. ; Camilleri, Michael ; Phillips, S. F. ; Aggarwal, A. ; Haddad, A. M. / Does the ileocolonic junction differentiate between solids and liquids?. In: Gut. 1993 ; Vol. 34, No. 2. pp. 222-226.
@article{552e37ec077449c487f107031362f14e,
title = "Does the ileocolonic junction differentiate between solids and liquids?",
abstract = "Previous observations from our laboratory have suggested that colonic filling from the ileum is characterised by a series of bolus movements. The present experiments were designed to test the hypothesis that bolus transit of ileal contents into the colon would not distinguish between solids and liquids. After a manometric infusion assembly was positioned by mouth into the ileum of 13 healthy volunteers, a mixture of nutrients (75 kcal), incorporating a solid phase radiolabel ( 111In labelled resin pellets) and a liquid phase marker ( 99mTc-DTPA), was infused into the ileum. Transit of both labels from the ileum to colon was quantified scintigraphically and ileal motility was also recorded. When markers were infused into the proximal ileum, 100 cm proximal to the ileocolonic junction (six), there were clear cut examples of discriminant transit, when liquids moved more rapidly from the small to the large bowel than did solids. When isotopes were instilled into the distal ileum, less than 50 cm from the ileocolonic junction, no separate transit of the solid and liquid phases was observed. No specific motor pattern of the ileum was regularly associated with bolus filling of the colon. These results support the hypothesis that the distal ileum can discriminate between solids and liquids but that the ileocecal junction cannot.",
author = "J. Hammer and Michael Camilleri and Phillips, {S. F.} and A. Aggarwal and Haddad, {A. M.}",
year = "1993",
language = "English (US)",
volume = "34",
pages = "222--226",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Does the ileocolonic junction differentiate between solids and liquids?

AU - Hammer, J.

AU - Camilleri, Michael

AU - Phillips, S. F.

AU - Aggarwal, A.

AU - Haddad, A. M.

PY - 1993

Y1 - 1993

N2 - Previous observations from our laboratory have suggested that colonic filling from the ileum is characterised by a series of bolus movements. The present experiments were designed to test the hypothesis that bolus transit of ileal contents into the colon would not distinguish between solids and liquids. After a manometric infusion assembly was positioned by mouth into the ileum of 13 healthy volunteers, a mixture of nutrients (75 kcal), incorporating a solid phase radiolabel ( 111In labelled resin pellets) and a liquid phase marker ( 99mTc-DTPA), was infused into the ileum. Transit of both labels from the ileum to colon was quantified scintigraphically and ileal motility was also recorded. When markers were infused into the proximal ileum, 100 cm proximal to the ileocolonic junction (six), there were clear cut examples of discriminant transit, when liquids moved more rapidly from the small to the large bowel than did solids. When isotopes were instilled into the distal ileum, less than 50 cm from the ileocolonic junction, no separate transit of the solid and liquid phases was observed. No specific motor pattern of the ileum was regularly associated with bolus filling of the colon. These results support the hypothesis that the distal ileum can discriminate between solids and liquids but that the ileocecal junction cannot.

AB - Previous observations from our laboratory have suggested that colonic filling from the ileum is characterised by a series of bolus movements. The present experiments were designed to test the hypothesis that bolus transit of ileal contents into the colon would not distinguish between solids and liquids. After a manometric infusion assembly was positioned by mouth into the ileum of 13 healthy volunteers, a mixture of nutrients (75 kcal), incorporating a solid phase radiolabel ( 111In labelled resin pellets) and a liquid phase marker ( 99mTc-DTPA), was infused into the ileum. Transit of both labels from the ileum to colon was quantified scintigraphically and ileal motility was also recorded. When markers were infused into the proximal ileum, 100 cm proximal to the ileocolonic junction (six), there were clear cut examples of discriminant transit, when liquids moved more rapidly from the small to the large bowel than did solids. When isotopes were instilled into the distal ileum, less than 50 cm from the ileocolonic junction, no separate transit of the solid and liquid phases was observed. No specific motor pattern of the ileum was regularly associated with bolus filling of the colon. These results support the hypothesis that the distal ileum can discriminate between solids and liquids but that the ileocecal junction cannot.

UR - http://www.scopus.com/inward/record.url?scp=0027460124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027460124&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 222

EP - 226

JO - Gut

JF - Gut

SN - 0017-5749

IS - 2

ER -