Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?

Ann Moyer, Shahrukh K. Hashmi, Cynthia Kroning, Steven R. De Goey, Mrinal M Patnaik, Mark R Litzow, Dennis A. Gastineau, William Hogan, Eapen K. Jacob, Justin D. Kreuter, Laurie L. Wakefield, Manish J. Gandhi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. Methods: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease. Results: Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were “indeterminate.” Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. Conclusions: In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Unrelated Donors
Hematopoietic Stem Cell Transplantation
Single Nucleotide Polymorphism
Stem Cells
Transplants
HLA-C Antigens
HLA-DRB1 Chains
Donor Selection
Recurrence
HLA-A Antigens
HLA-B Antigens
Survival
Graft vs Host Disease
Multivariate Analysis
Tissue Donors

Keywords

  • Allogeneic stem cell transplantation
  • MHC Class III
  • MHC gamma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes? / Moyer, Ann; Hashmi, Shahrukh K.; Kroning, Cynthia; De Goey, Steven R.; Patnaik, Mrinal M; Litzow, Mark R; Gastineau, Dennis A.; Hogan, William; Jacob, Eapen K.; Kreuter, Justin D.; Wakefield, Laurie L.; Gandhi, Manish J.

In: Human Immunology, 01.01.2018.

Research output: Contribution to journalArticle

Moyer, Ann ; Hashmi, Shahrukh K. ; Kroning, Cynthia ; De Goey, Steven R. ; Patnaik, Mrinal M ; Litzow, Mark R ; Gastineau, Dennis A. ; Hogan, William ; Jacob, Eapen K. ; Kreuter, Justin D. ; Wakefield, Laurie L. ; Gandhi, Manish J. / Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?. In: Human Immunology. 2018.
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abstract = "Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. Methods: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease. Results: Of 66 donor-recipient pairs, 26(39.4{\%}) were gamma-type matches, 34(51.5{\%}) were mismatches, and 6(9.1{\%}) were “indeterminate.” Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. Conclusions: In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.",
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author = "Ann Moyer and Hashmi, {Shahrukh K.} and Cynthia Kroning and {De Goey}, {Steven R.} and Patnaik, {Mrinal M} and Litzow, {Mark R} and Gastineau, {Dennis A.} and William Hogan and Jacob, {Eapen K.} and Kreuter, {Justin D.} and Wakefield, {Laurie L.} and Gandhi, {Manish J.}",
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AU - Moyer, Ann

AU - Hashmi, Shahrukh K.

AU - Kroning, Cynthia

AU - De Goey, Steven R.

AU - Patnaik, Mrinal M

AU - Litzow, Mark R

AU - Gastineau, Dennis A.

AU - Hogan, William

AU - Jacob, Eapen K.

AU - Kreuter, Justin D.

AU - Wakefield, Laurie L.

AU - Gandhi, Manish J.

PY - 2018/1/1

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N2 - Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. Methods: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease. Results: Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were “indeterminate.” Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. Conclusions: In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.

AB - Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. Methods: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease. Results: Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were “indeterminate.” Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. Conclusions: In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.

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