Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?

Ann Moyer, Shahrukh K. Hashmi, Cynthia Kroning, Steven R. De Goey, Mrinal M Patnaik, Mark R Litzow, Dennis A. Gastineau, William Hogan, Eapen K. Jacob, Justin D. Kreuter, Laurie L. Wakefield, Manish J. Gandhi

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. Methods: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease. Results: Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were “indeterminate.” Matching status was not associated with overall survival (p = 0.43), relapse (p = 0.21), acute GVHD (p = 0.43), severe aGVHD (p = 0.31), or chronic GVHD (p = 0.23) in univariate analyses, nor in multivariate analyses (p = 0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status. Conclusions: In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Allogeneic stem cell transplantation
  • MHC Class III
  • MHC gamma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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