Does aging adversely affect muscle mitochondrial function?

Kevin R. Short, K. Sreekumaran Nair

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalExercise and sport sciences reviews
Volume29
Issue number3
DOIs
StatePublished - Jul 2001

Keywords

  • Cytochrome c oxidase
  • MRNA
  • MtDNA
  • Oxidative damage
  • Oxidative phosphorylation
  • Protein synthesis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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