DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates

Robin Patel; Jim R. Uhl; Peggy Kohner; Marlene K. Hopkins; James M. Steckelberg; Bruce Kline; Franklin R. Cockerill

doi:10.1128/aac.42.1.202

DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates

Robin Patel, Jim R. Uhl, Peggy Kohner, Marlene K. Hopkins, James M. Steckelberg, Bruce Kline, Franklin R. Cockerill

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2 gene exhibited between 0 and 23 base pair changes per 346 bp studied when the vanC-2 sequences were compared to that of the reference strain E. casseliflavus ATCC 25788. Little variation was noted in the vanA and vanC-1 genes.

Original language	English (US)
Pages (from-to)	202-205
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	42
Issue number	1
DOIs	https://doi.org/10.1128/aac.42.1.202
State	Published - Jan 1998

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2 gene exhibited between 0 and 23 base pair changes per 346 bp studied when the vanC-2 sequences were compared to that of the reference strain E. casseliflavus ATCC 25788. Little variation was noted in the vanA and vanC-1 genes.",

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AU - Steckelberg, James M.

AU - Kline, Bruce

AU - Cockerill, Franklin R.

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AB - We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2 gene exhibited between 0 and 23 base pair changes per 346 bp studied when the vanC-2 sequences were compared to that of the reference strain E. casseliflavus ATCC 25788. Little variation was noted in the vanA and vanC-1 genes.

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DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates

Abstract

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