DNA methylation in health and disease

Keith D. Robertson; Alan P. Wolffe

doi:10.1038/35049533

DNA methylation in health and disease

Keith D. Robertson, Alan P. Wolffe

Pharmacology

Research output: Contribution to journal › Review article › peer-review

824 Scopus citations

Abstract

DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.

Original language	English (US)
Pages (from-to)	11-19
Number of pages	9
Journal	Nature Reviews Genetics
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/35049533
State	Published - Oct 2000

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1038/35049533

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DNA methylation in health and disease

Abstract

ASJC Scopus subject areas

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