DNA methylation in health and disease

Keith D. Robertson, Alan P. Wolffe

Research output: Contribution to journalReview article

797 Scopus citations

Abstract

DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalNature Reviews Genetics
Volume1
Issue number1
DOIs
StatePublished - Oct 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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