DNA demethylation and epigenetics

Xiaofei Zhang; Thomas E. Witzig; Xiaosheng Wu

doi:10.1007/978-3-319-55530-0_120

DNA demethylation and epigenetics

Xiaofei Zhang, Thomas E. Witzig, Xiaosheng Wu

Hematology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epigenetic regulation is essential to gene expression programs necessary for normal embryonic development and maintaining cell functions throughout life. DNA methylation on cytosine nucleotides dictates those gene expression programs. However, the steady state levels and patterns of DNA methylation are maintained through the dynamic balance of DNA methylation and demethylation, and changing either side of the balance will certainly lead to the development of disease. In this chapter, we will briefly discuss recent advances on DNA demethylation and the implications in health and disease.

Original language	English (US)
Title of host publication	Handbook of Nutrition, Diet, and Epigenetics
Publisher	Springer International Publishing
Pages	281-292
Number of pages	12
Volume	1
ISBN (Electronic)	9783319555300
ISBN (Print)	9783319555294
DOIs	https://doi.org/10.1007/978-3-319-55530-0_120
State	Published - Jan 5 2019

Keywords

5caC
5fC
5hmC
AID
Apobec
Ascorbic acid
BER
DNA demethylation
DNA repair
DNMT1
DNMT3a
DNMT3b
IDH
Somatic hypermutation
TDG
TET
UNG

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-3-319-55530-0_120

Cite this

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AU - Wu, Xiaosheng

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AB - Epigenetic regulation is essential to gene expression programs necessary for normal embryonic development and maintaining cell functions throughout life. DNA methylation on cytosine nucleotides dictates those gene expression programs. However, the steady state levels and patterns of DNA methylation are maintained through the dynamic balance of DNA methylation and demethylation, and changing either side of the balance will certainly lead to the development of disease. In this chapter, we will briefly discuss recent advances on DNA demethylation and the implications in health and disease.

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KW - DNMT3a

KW - DNMT3b

KW - IDH

KW - Somatic hypermutation

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KW - UNG

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DNA demethylation and epigenetics

Abstract

Keywords

ASJC Scopus subject areas

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