DNA demethylation and epigenetics

Xiaofei Zhang, Thomas E. Witzig, Xiaosheng Wu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epigenetic regulation is essential to gene expression programs necessary for normal embryonic development and maintaining cell functions throughout life. DNA methylation on cytosine nucleotides dictates those gene expression programs. However, the steady state levels and patterns of DNA methylation are maintained through the dynamic balance of DNA methylation and demethylation, and changing either side of the balance will certainly lead to the development of disease. In this chapter, we will briefly discuss recent advances on DNA demethylation and the implications in health and disease.

Original languageEnglish (US)
Title of host publicationHandbook of Nutrition, Diet, and Epigenetics
PublisherSpringer International Publishing
Pages281-292
Number of pages12
Volume1
ISBN (Electronic)9783319555300
ISBN (Print)9783319555294
DOIs
StatePublished - Jan 5 2019

Keywords

  • 5caC
  • 5fC
  • 5hmC
  • AID
  • Apobec
  • Ascorbic acid
  • BER
  • DNA demethylation
  • DNA repair
  • DNMT1
  • DNMT3a
  • DNMT3b
  • IDH
  • Somatic hypermutation
  • TDG
  • TET
  • UNG

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Zhang, X., Witzig, T. E., & Wu, X. (2019). DNA demethylation and epigenetics. In Handbook of Nutrition, Diet, and Epigenetics (Vol. 1, pp. 281-292). Springer International Publishing. https://doi.org/10.1007/978-3-319-55530-0_120