TY - JOUR
T1 - Dissecting karyotypic patterns in non-hyperdiploid multiple myeloma
T2 - An overview on the karyotypic evolution
AU - Jimenez-Zepeda, Victor H.
AU - Braggio, Esteban
AU - Fonseca, Rafael
PY - 2013/10
Y1 - 2013/10
N2 - Background Multiple myeloma (MM) is a plasma cell disorder characterized by the presence of specific genetic and cytogenetic aberrations that define unique subgroups with different outcomes. On the basis of the ploidy status, MM can be subdivided into hyperdiploid MM (H-MM) and non-hyperdiploid MM (NH-MM). NH-MM is an entity that encompasses hypodiploid, pseudodiploid, and near tetraploid MM and is associated with a higher number of immunoglobulin heavy-chain (IgH) translocations. Materials and Methods We have systematically analyzed the structure of the karyotypic evolution in NH-MM and identified several genetic features of their complex karyotypic patterns. Results On the basis of statistical models used in complex karyotypes, we were able to identify the temporal order in which the genetic aberrations occur in NH-MM. In this analysis, whole chromosome losses and IgH translocations were commonly seen, and -13/13q- and t14q32 were defined as early genetic events in the karyotypic evolution of NH-MM. Furthermore, chromosome 1 and 17 abnormalities were associated with a late karyotypic phase of evolution consistent with the recognized pattern of acquired events deemed to be associated with these type of genetic aberrations. Conclusion Accumulation of genetic aberrations in NH-MM above a threshold results in malignant transformation.
AB - Background Multiple myeloma (MM) is a plasma cell disorder characterized by the presence of specific genetic and cytogenetic aberrations that define unique subgroups with different outcomes. On the basis of the ploidy status, MM can be subdivided into hyperdiploid MM (H-MM) and non-hyperdiploid MM (NH-MM). NH-MM is an entity that encompasses hypodiploid, pseudodiploid, and near tetraploid MM and is associated with a higher number of immunoglobulin heavy-chain (IgH) translocations. Materials and Methods We have systematically analyzed the structure of the karyotypic evolution in NH-MM and identified several genetic features of their complex karyotypic patterns. Results On the basis of statistical models used in complex karyotypes, we were able to identify the temporal order in which the genetic aberrations occur in NH-MM. In this analysis, whole chromosome losses and IgH translocations were commonly seen, and -13/13q- and t14q32 were defined as early genetic events in the karyotypic evolution of NH-MM. Furthermore, chromosome 1 and 17 abnormalities were associated with a late karyotypic phase of evolution consistent with the recognized pattern of acquired events deemed to be associated with these type of genetic aberrations. Conclusion Accumulation of genetic aberrations in NH-MM above a threshold results in malignant transformation.
KW - Cytogenetics
KW - Multiple myeloma
KW - Time to occurrence
UR - http://www.scopus.com/inward/record.url?scp=84884147873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884147873&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2013.05.005
DO - 10.1016/j.clml.2013.05.005
M3 - Article
C2 - 23856591
AN - SCOPUS:84884147873
SN - 2152-2650
VL - 13
SP - 552
EP - 558
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 5
ER -